HCSGD entry for PANX1
1. General information
| Official gene symbol | PANX1 |
|---|---|
| Entrez ID | 24145 |
| Gene full name | pannexin 1 |
| Other gene symbols | MRS1 PX1 UNQ2529 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002020 | Protease binding | IEA | molecular_function |
| GO:0002931 | Response to ischemia | IEA | biological_process |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005262 | Calcium channel activity | IMP | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005921 | Gap junction | IEA | cellular_component |
| GO:0006812 | Cation transport | IDA | biological_process |
| GO:0006816 | Calcium ion transport | IMP | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0022840 | Leak channel activity | IMP | molecular_function |
| GO:0032059 | Bleb | IDA | cellular_component |
| GO:0033198 | Response to ATP | IEA | biological_process |
| GO:0034214 | Protein hexamerization | IDA | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044325 | Ion channel binding | IEA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0050717 | Positive regulation of interleukin-1 alpha secretion | IEA | biological_process |
| GO:0050718 | Positive regulation of interleukin-1 beta secretion | IDA | biological_process |
| GO:0051015 | Actin filament binding | IEA | molecular_function |
| GO:0055077 | Gap junction hemi-channel activity | IDA | molecular_function |
| GO:0097110 | Scaffold protein binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0330405684 | 0.5991161430 | 0.4186675481 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1652821634 |
| GSE13712_SHEAR | Up | 1.0577682124 |
| GSE13712_STATIC | Up | 0.4933530197 |
| GSE19018 | Down | -0.3889367952 |
| GSE19899_A1 | Up | 0.0260541629 |
| GSE19899_A2 | Up | 0.1062300192 |
| PubMed_21979375_A1 | Up | 0.4911514231 |
| PubMed_21979375_A2 | Up | 0.3691252430 |
| GSE35957 | Down | -0.0483599283 |
| GSE36640 | Down | -0.5209628538 |
| GSE54402 | Up | 0.4766216092 |
| GSE9593 | Up | 0.3675629884 |
| GSE43922 | Up | 0.4684664587 |
| GSE24585 | Down | -0.2909048422 |
| GSE37065 | Up | 0.3367860650 |
| GSE28863_A1 | Up | 0.2124070179 |
| GSE28863_A2 | Up | 0.9591097404 |
| GSE28863_A3 | Down | -0.6623473942 |
| GSE28863_A4 | Up | 0.0973863718 |
| GSE48662 | Down | -0.0231250791 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Probenecid | DB01032 | APRD00167 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001433 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004125 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004125 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021301 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025607 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
