HCSGD entry for ALOX5AP


1. General information

Official gene symbolALOX5AP
Entrez ID241
Gene full namearachidonate 5-lipoxygenase-activating protein
Other gene symbolsFLAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002540Leukotriene production involved in inflammatory responseIEAbiological_process
GO:0002675Positive regulation of acute inflammatory responseIEAbiological_process
GO:0004364Glutathione transferase activityIBAmolecular_function
GO:0004464Leukotriene-C4 synthase activityIBAmolecular_function
GO:0004602Glutathione peroxidase activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005635Nuclear envelopeIDA TAScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006691Leukotriene metabolic processTASbiological_process
GO:0008047Enzyme activator activityIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019370Leukotriene biosynthetic processIDAbiological_process
GO:0019372Lipoxygenase pathwayTASbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0031965Nuclear membraneIDAcellular_component
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050544Arachidonic acid bindingIDAmolecular_function
GO:0070207Protein homotrimerizationIPIbiological_process
GO:0071277Cellular response to calcium ionIDAbiological_process
GO:2001300Lipoxin metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07716680980.89373192510.58668619301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1101473838
GSE13712_SHEARUp0.2710053114
GSE13712_STATICUp0.1721053324
GSE19018Up0.3078099755
GSE19899_A1Up0.2859313447
GSE19899_A2Up0.7257638985
PubMed_21979375_A1Up0.2574121541
PubMed_21979375_A2Up0.5269718428
GSE35957Down-0.1229679460
GSE36640Up0.2958408956
GSE54402Up0.1337549004
GSE9593Up0.0930386754
GSE43922Up0.8205969968
GSE24585Down-0.0541115975
GSE37065Down-0.0610457834
GSE28863_A1Down-0.2386033018
GSE28863_A2Down-0.2112974191
GSE28863_A3Up0.1721482117
GSE28863_A4Up0.0666060505
GSE48662Down-0.2101459462

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DG031DB04929 -
AM103DB05225 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-135a-5pMIMAT0000428NAhsa-miR-135a20194722
hsa-miR-199a-5pMIMAT0000231NAhsa-miR-199a-5p20194722
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.