HCSGD entry for ALOX5AP
1. General information
Official gene symbol | ALOX5AP |
---|---|
Entrez ID | 241 |
Gene full name | arachidonate 5-lipoxygenase-activating protein |
Other gene symbols | FLAP |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0002540 | Leukotriene production involved in inflammatory response | IEA | biological_process |
GO:0002675 | Positive regulation of acute inflammatory response | IEA | biological_process |
GO:0004364 | Glutathione transferase activity | IBA | molecular_function |
GO:0004464 | Leukotriene-C4 synthase activity | IBA | molecular_function |
GO:0004602 | Glutathione peroxidase activity | IBA | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005635 | Nuclear envelope | IDA TAS | cellular_component |
GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
GO:0005829 | Cytosol | IEA | cellular_component |
GO:0006691 | Leukotriene metabolic process | TAS | biological_process |
GO:0008047 | Enzyme activator activity | IEA | molecular_function |
GO:0016021 | Integral component of membrane | IEA | cellular_component |
GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
GO:0019370 | Leukotriene biosynthetic process | IDA | biological_process |
GO:0019372 | Lipoxygenase pathway | TAS | biological_process |
GO:0019899 | Enzyme binding | IEA | molecular_function |
GO:0031965 | Nuclear membrane | IDA | cellular_component |
GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
GO:0044281 | Small molecule metabolic process | TAS | biological_process |
GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
GO:0050544 | Arachidonic acid binding | IDA | molecular_function |
GO:0070207 | Protein homotrimerization | IPI | biological_process |
GO:0071277 | Cellular response to calcium ion | IDA | biological_process |
GO:2001300 | Lipoxin metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0771668098 | 0.8937319251 | 0.5866861930 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.1101473838 |
GSE13712_SHEAR | Up | 0.2710053114 |
GSE13712_STATIC | Up | 0.1721053324 |
GSE19018 | Up | 0.3078099755 |
GSE19899_A1 | Up | 0.2859313447 |
GSE19899_A2 | Up | 0.7257638985 |
PubMed_21979375_A1 | Up | 0.2574121541 |
PubMed_21979375_A2 | Up | 0.5269718428 |
GSE35957 | Down | -0.1229679460 |
GSE36640 | Up | 0.2958408956 |
GSE54402 | Up | 0.1337549004 |
GSE9593 | Up | 0.0930386754 |
GSE43922 | Up | 0.8205969968 |
GSE24585 | Down | -0.0541115975 |
GSE37065 | Down | -0.0610457834 |
GSE28863_A1 | Down | -0.2386033018 |
GSE28863_A2 | Down | -0.2112974191 |
GSE28863_A3 | Up | 0.1721482117 |
GSE28863_A4 | Up | 0.0666060505 |
GSE48662 | Down | -0.2101459462 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
---|---|---|---|---|---|---|---|
hsa-miR-135a-5p | MIMAT0000428 | NA | hsa-miR-135a | 20194722 | |||
hsa-miR-199a-5p | MIMAT0000231 | NA | hsa-miR-199a-5p | 20194722 |
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