HCSGD entry for ALOX5
1. General information
| Official gene symbol | ALOX5 |
|---|---|
| Entrez ID | 240 |
| Gene full name | arachidonate 5-lipoxygenase |
| Other gene symbols | 5-LO 5-LOX 5LPG LOG5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002540 | Leukotriene production involved in inflammatory response | IEA | biological_process |
| GO:0004051 | Arachidonate 5-lipoxygenase activity | IDA | molecular_function |
| GO:0005506 | Iron ion binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005635 | Nuclear envelope | IDA TAS | cellular_component |
| GO:0005641 | Nuclear envelope lumen | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006691 | Leukotriene metabolic process | TAS | biological_process |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019370 | Leukotriene biosynthetic process | IDA | biological_process |
| GO:0019372 | Lipoxygenase pathway | TAS | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:2001300 | Lipoxin metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6459929752 | 0.6984165457 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1656533710 |
| GSE13712_SHEAR | Up | 0.1410784989 |
| GSE13712_STATIC | Down | -0.0598249195 |
| GSE19018 | Up | 0.0314569818 |
| GSE19899_A1 | Up | 0.0812629239 |
| GSE19899_A2 | Up | 0.0478248107 |
| PubMed_21979375_A1 | Up | 0.0891202102 |
| PubMed_21979375_A2 | Down | -0.0454290232 |
| GSE35957 | Down | -0.0167623216 |
| GSE36640 | Down | -0.0003344664 |
| GSE54402 | Down | -0.0133769787 |
| GSE9593 | Up | 0.0529813236 |
| GSE43922 | Up | 0.0275357996 |
| GSE24585 | Up | 0.6752911087 |
| GSE37065 | Down | -0.0993473334 |
| GSE28863_A1 | Down | -0.3027843061 |
| GSE28863_A2 | Down | -0.2866428160 |
| GSE28863_A3 | Up | 0.3214652003 |
| GSE28863_A4 | Up | 0.0715568586 |
| GSE48662 | Up | 0.0260342216 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin E | DB00163 | NUTR00061 | EXPT03227 |
| Aminosalicylic Acid | DB00233 | APRD00749 | EXPT00693 |
| Diclofenac | DB00586 | APRD00527 |
| Diethylcarbamazine | DB00711 | APRD00918 |
| Zileuton | DB00744 | APRD00265 |
| Meclofenamic acid | DB00939 | APRD01090 |
| Minocycline | DB01017 | APRD00547 |
| Hyperforin | DB01892 | EXPT01804 |
| Licofelone | DB04725 | - |
| MLN-977 | DB05431 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
