HCSGD entry for ABCA4

1. General information

Official gene symbolABCA4
Entrez ID24
Gene full nameATP-binding cassette, sub-family A (ABC1), member 4
Other gene symbolsABC10 ABCR ARMD2 CORD3 FFM RMP RP19 STGD STGD1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0004012Phospholipid-translocating ATPase activityIEAmolecular_function
GO:0005215Transporter activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006200ATP catabolic processTASbiological_process
GO:0006649Phospholipid transfer to membraneIEAbiological_process
GO:0006810TransportTASbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016887ATPase activityIEAmolecular_function
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEAmolecular_function
GO:0045494Photoreceptor cell maintenanceIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0097381Photoreceptor disc membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22282562210.97541610500.90402897931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0995845682
GSE13712_SHEARDown-0.1137984767
GSE13712_STATICDown-0.0631813514
GSE19018Up0.0413939570
GSE19899_A1Up0.1259915987
GSE19899_A2Up0.2132338892
PubMed_21979375_A1Up0.7481509145
PubMed_21979375_A2Up0.1674177769
GSE35957Up0.2599270919
GSE36640Up0.1887416328
GSE54402Up0.1155375832
GSE9593Up0.0820257285
GSE43922Up0.0397933615
GSE24585Up0.0052184751
GSE37065Up0.0840186514
GSE28863_A1Down-0.0974041076
GSE28863_A2Up0.2460954182
GSE28863_A3Up0.1403268532
GSE28863_A4Up0.0856380883
GSE48662Up0.2016444875

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017969MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25972055We studied whether personality traits in late adulthood, as defined in the five-factor model (FFM), were associated with a biomarker of cellular vitality, leukocyte telomere length (LTL)
25972055RESULTS: None of the FFM personality dimensions were significantly associated with the LTL in the analyses of both sexes combined
25972055CONCLUSIONS: FFM dimensions of personality were not associated with LTL in a sample of elderly individuals
23964074The P2X7R was expressed on apical and basolateral membranes of mouse RPE; mRNA expression of P2X7R and extracellular ATP marker NTPDase1 was raised in RPE tissue from the ABCA4(-/-) mouse model of Stargardt's retinal degeneration
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