HCSGD entry for CADM1

1. General information

Official gene symbolCADM1
Entrez ID23705
Gene full namecell adhesion molecule 1
Other gene symbolsBL2 IGSF4 IGSF4A NECL2 Necl-2 RA175 ST17 SYNCAM TSLC1 sTSLC-1 sgIGSF synCAM1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentIEAbiological_process
GO:0001913T cell mediated cytotoxicityIDAbiological_process
GO:0005102Receptor bindingIEA IPI ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005911Cell-cell junctionIEA ISScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007156Homophilic cell adhesionIEA ISSbiological_process
GO:0007157Heterophilic cell-cell adhesionIEA ISSbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007416Synapse assemblyIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008022Protein C-terminus bindingIEA ISSmolecular_function
GO:0008037Cell recognitionIDA IEA ISSbiological_process
GO:0009826Unidimensional cell growthIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEA ISScellular_component
GO:0016338Calcium-independent cell-cell adhesionIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030165PDZ domain bindingIEA ISSmolecular_function
GO:0030424AxonIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0034329Cell junction assemblyTASbiological_process
GO:0034332Adherens junction organizationTASbiological_process
GO:0042271Susceptibility to natural killer cell mediated cytotoxicityIDA IEA ISSbiological_process
GO:0042803Protein homodimerization activityIEA ISSmolecular_function
GO:0045216Cell-cell junction organizationTASbiological_process
GO:0045954Positive regulation of natural killer cell mediated cytotoxicityIDA ISSbiological_process
GO:0050715Positive regulation of cytokine secretionIDAbiological_process
GO:0050798Activated T cell proliferationIDAbiological_process
GO:0050839Cell adhesion molecule bindingIEAmolecular_function
GO:0051606Detection of stimulusIDA IEA ISSbiological_process
GO:0060348Bone developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51256093230.12006721630.99999024730.6658847872

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1515317318
GSE13712_SHEARDown-0.1699232018
GSE13712_STATICDown-0.3658987459
GSE19018Down-0.0578953341
GSE19899_A1Down-0.1006450081
GSE19899_A2Down-0.6673677345
PubMed_21979375_A1Down-1.2249283744
PubMed_21979375_A2Down-0.1533629652
GSE35957Up1.1327612262
GSE36640Up0.5796764966
GSE54402Down-0.6521652042
GSE9593Up0.0263040651
GSE43922Down-0.0729337388
GSE24585Up0.4057424676
GSE37065Down-0.1856316776
GSE28863_A1Down-0.1287641163
GSE28863_A2Up0.0548213471
GSE28863_A3Up0.3010294453
GSE28863_A4Up0.0603593772
GSE48662Down-0.1354624131

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-15a-5pMIMAT0000068MIRT003888Reporter assay//qRT-PCRFunctional MTI18362358
hsa-miR-192-5pMIMAT0000222MIRT004167MicroarrayFunctional MTI (Weak)16822819
hsa-miR-16-5pMIMAT0000069MIRT004382Reporter assay//qRT-PCRFunctional MTI18362358
hsa-miR-26b-5pMIMAT0000083MIRT029576MicroarrayFunctional MTI (Weak)19088304
hsa-miR-877-3pMIMAT0004950MIRT036901CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042379CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-15a-5pMIMAT0000068NAhsa-miR-15a18362358
hsa-miR-16-5pMIMAT0000069NAhsa-miR-1618362358
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24164458We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells
23763475The present study found that H2 O2 (25-100 mumol/L) decreased iPSC adhesion to matrix proteins and endothelial cells, and downregulated gene expression levels of adhesion-related molecules, such as integrin alpha 7, cadherin 1 and 5, melanoma cell adhesion molecule, vascular cell adhesion molecule 1, and monocyte chemoattractant protein-1
21144825It has been shown that expression of vascular cell adhesion molecule-1 (VCAM-1) was most markedly decreased among the tested markers in the senescent MSCs
20664062The cells are resistant to tumor necrosis factor (TNF)alpha-induced apoptosis, adhesion of neutrophils and mononuclear cells, and the surface (but not cytoplasmic) expression of endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1
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