HCSGD entry for SLC7A11
1. General information
| Official gene symbol | SLC7A11 |
|---|---|
| Entrez ID | 23657 |
| Gene full name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
| Other gene symbols | CCBR1 xCT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005791 | Rough endoplasmic reticulum | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006835 | Dicarboxylic acid transport | TAS | biological_process |
| GO:0006865 | Amino acid transport | TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009636 | Response to toxic substance | IDA | biological_process |
| GO:0015171 | Amino acid transmembrane transporter activity | IEA | molecular_function |
| GO:0015327 | Cystine:glutamate antiporter activity | TAS | molecular_function |
| GO:0015800 | Acidic amino acid transport | TAS | biological_process |
| GO:0015804 | Neutral amino acid transport | TAS | biological_process |
| GO:0015807 | L-amino acid transport | TAS | biological_process |
| GO:0015813 | L-glutamate transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0035094 | Response to nicotine | IEA | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070306 | Lens fiber cell differentiation | IEA | biological_process |
| GO:0070527 | Platelet aggregation | IEA | biological_process |
| GO:0072337 | Modified amino acid transport | TAS | biological_process |
| GO:1902475 | L-alpha-amino acid transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0156501197 | 0.0089981726 | 0.3099524454 | 0.1878893903 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9119352100 |
| GSE13712_SHEAR | Up | 1.4453614210 |
| GSE13712_STATIC | Up | 0.5420929232 |
| GSE19018 | Up | 0.8768373914 |
| GSE19899_A1 | Down | -1.9922684816 |
| GSE19899_A2 | Down | -1.0257079044 |
| PubMed_21979375_A1 | Down | -0.1936027886 |
| PubMed_21979375_A2 | Down | -0.5370000846 |
| GSE35957 | Down | -0.3459006355 |
| GSE36640 | Up | 1.5027003239 |
| GSE54402 | Down | -1.0173823230 |
| GSE9593 | Up | 0.7540907384 |
| GSE43922 | Up | 0.1897628652 |
| GSE24585 | Down | -0.8918560014 |
| GSE37065 | Up | 0.7153896931 |
| GSE28863_A1 | Up | 0.0198308001 |
| GSE28863_A2 | Down | -0.9849668189 |
| GSE28863_A3 | Down | -1.0858200889 |
| GSE28863_A4 | Down | -0.1349309242 |
| GSE48662 | Up | 0.7070594913 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Cystine | DB00138 | NUTR00023 |
| L-Glutamic Acid | DB00142 | NUTR00027 |
| Riluzole | DB00740 | APRD00145 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003108 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005145 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019496 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019651 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020896 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022074 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024370 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025179 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026724 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028377 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029918 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
