HCSGD entry for PLD3
1. General information
| Official gene symbol | PLD3 |
|---|---|
| Entrez ID | 23646 |
| Gene full name | phospholipase D family, member 3 |
| Other gene symbols | HU-K4 HUK4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004630 | Phospholipase D activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006655 | Phosphatidylglycerol biosynthetic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0070290 | NAPE-specific phospholipase D activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0227925725 | 0.6590157099 | 0.3606136091 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3965075251 |
| GSE13712_SHEAR | Down | -0.1963077342 |
| GSE13712_STATIC | Up | 0.0841322912 |
| GSE19018 | Up | 0.2236693005 |
| GSE19899_A1 | Down | -0.5053836318 |
| GSE19899_A2 | Up | 0.0536924808 |
| PubMed_21979375_A1 | Up | 0.1798202593 |
| PubMed_21979375_A2 | Up | 0.7130868812 |
| GSE35957 | Down | -0.2322945602 |
| GSE36640 | Up | 0.8273157550 |
| GSE54402 | Down | -0.1227143861 |
| GSE9593 | Up | 0.6992579282 |
| GSE43922 | Down | -0.0203535205 |
| GSE24585 | Up | 0.7600936579 |
| GSE37065 | Down | -0.0027649175 |
| GSE28863_A1 | Up | 0.4625863958 |
| GSE28863_A2 | Up | 0.3905619828 |
| GSE28863_A3 | Down | -0.1500478137 |
| GSE28863_A4 | Down | -0.1638323568 |
| GSE48662 | Up | 0.9236957966 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017099 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037314 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042303 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044846 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051205 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25412306 | We identified 107 proteins that could be potential markers of senescence and validated 10 of them (DEP1, NTAL, EBP50, STX4, VAMP3, ARMX3, B2MG, LANCL1, VPS26A and PLD3) |
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