HCSGD entry for PPP1R15A

1. General information

Official gene symbolPPP1R15A
Entrez ID23645
Gene full nameprotein phosphatase 1, regulatory subunit 15A
Other gene symbolsGADD34
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006417Regulation of translationIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusTASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00051652290.98387294940.06387395351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.4324361155
GSE13712_SHEARUp0.2101270023
GSE13712_STATICUp0.3792598815
GSE19018Down-0.1859065214
GSE19899_A1Up0.6296297369
GSE19899_A2Up1.6548982095
PubMed_21979375_A1Up2.4162749655
PubMed_21979375_A2Up1.6261161280
GSE35957Up0.2917927169
GSE36640Up0.1531821996
GSE54402Up1.1150231630
GSE9593Up0.9951602698
GSE43922Down-0.0176369089
GSE24585Up0.2249763628
GSE37065Up0.1523566220
GSE28863_A1Up0.2465742317
GSE28863_A2Up0.5861512803
GSE28863_A3Up0.4684139253
GSE28863_A4Down-0.0786124753
GSE48662Up0.3944819922

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT050807CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22788682ER stress was detected by assays for glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), and growth arrest and DNA damage-inducible protein 34 (GADD34) mRNA, and transient phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha)
17487408GADD34 induces p21 expression and cellular senescence
17487408We previously identified GADD34 (growth arrest and DNA damage protein 34) by screening for genes involved in oncogenic-transformation and/or cellular senescence in Ras-transformed rat F2408 fibroblasts (7EJ-Ras), which exhibit anchorage-independent growth and do not senesce
17487408In the current study, we found that transduction of 7EJ-Ras cells with a retroviral vector expressing GADD34 suppressed their proliferation
17487408Whereas the expression of p21 was decreased in GADD34 KO MEFs, its expression was rescued in these cells by ectopic expression of GADD34 by retroviral transduction
17487408These findings suggest that GADD34 contributes to the regulation of p21 expression, and that it suppresses cellular proliferation through the induction of cellular senescence
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