HCSGD entry for SMUG1
1. General information
| Official gene symbol | SMUG1 |
|---|---|
| Entrez ID | 23583 |
| Gene full name | single-strand-selective monofunctional uracil-DNA glycosylase 1 |
| Other gene symbols | FDG HMUDG UNG3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000703 | Oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004844 | Uracil DNA N-glycosylase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | IDA IEA TAS | biological_process |
| GO:0006285 | Base-excision repair, AP site formation | TAS | biological_process |
| GO:0017065 | Single-strand selective uracil DNA N-glycosylase activity | IDA IEA | molecular_function |
| GO:0019104 | DNA N-glycosylase activity | IDA | molecular_function |
| GO:0045008 | Depyrimidination | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7951416664 | 0.6531953991 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0030850520 |
| GSE13712_SHEAR | Down | -0.0177458451 |
| GSE13712_STATIC | Down | -0.1436731310 |
| GSE19018 | Up | 0.0083268778 |
| GSE19899_A1 | Down | -0.1400606594 |
| GSE19899_A2 | Up | 0.1454844347 |
| PubMed_21979375_A1 | Up | 0.4195727435 |
| PubMed_21979375_A2 | Up | 0.1476059360 |
| GSE35957 | Down | -0.0108581307 |
| GSE36640 | Down | -0.0767390062 |
| GSE54402 | Down | -0.0090278163 |
| GSE9593 | Up | 0.1000702934 |
| GSE43922 | Up | 0.0419427945 |
| GSE24585 | Down | -0.0609297723 |
| GSE37065 | Up | 0.0301817780 |
| GSE28863_A1 | Down | -0.2644964131 |
| GSE28863_A2 | Down | -0.1003599189 |
| GSE28863_A3 | Down | -0.1450336356 |
| GSE28863_A4 | Up | 0.0558796750 |
| GSE48662 | Up | 0.2543974025 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027837 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039050 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044695 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16154306 | Using fluorescein di-beta-d-galactopyranoside (FDG) method for SA-betaG detection, we showed that senescent human foreskin fibroblast Hs68 cells did not express a specific enzyme that has a maximal activity at pH 6 |
| 14751269 | Here, we modified the X-Gal method by replacing X-Gal with fluorescein di-beta-D-galactopyranoside (FDG) as substrate for SA-betaG, and the activity was measured fluorimetrically |
| 14751269 | We showed in Hs68 cells that the FDG fluorescein fluorescence increased with increasing passages of the cells in parallel with the X-Gal method |
| 14751269 | A major advantage of the FDG method is that it is a quantitative method for the SA-betaG activity |
| 14751269 | For example, we showed that the FDG fluorescein in p30(+1) of Hs68 cells was generally stronger than that in p26(+1) cells, whereas the X-Gal method gave similar results (95 and 100%) for p26(+1) and p30(+1) cells |
| 14751269 | The FDG method was precise with a relative standard deviation lower than 10% |
| 14751269 | We further demonstrated that FDG and X-Gal could be added simultaneously for SA-betaG assay because the FDG fluorescein diffused readily through formaldehyde-fixed cell membrane and could be detected in the suspension buffer |
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