HCSGD entry for CASP14
1. General information
| Official gene symbol | CASP14 |
|---|---|
| Entrez ID | 23581 |
| Gene full name | caspase 14, apoptosis-related cysteine peptidase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004197 | Cysteine-type endopeptidase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0031424 | Keratinization | TAS | biological_process |
| GO:0045095 | Keratin filament | IEA | cellular_component |
| GO:0070268 | Cornification | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5970953687 | 0.5815859998 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0479154968 |
| GSE13712_SHEAR | Down | -0.0886406379 |
| GSE13712_STATIC | Down | -0.0604438614 |
| GSE19018 | Up | 0.0290540462 |
| GSE19899_A1 | Up | 0.1459081366 |
| GSE19899_A2 | Up | 0.1175618954 |
| PubMed_21979375_A1 | Up | 0.2464394872 |
| PubMed_21979375_A2 | Down | -0.1528072982 |
| GSE35957 | Up | 0.1157290990 |
| GSE36640 | Up | 0.3241036738 |
| GSE54402 | Down | -0.1344708103 |
| GSE9593 | Up | 0.2210544801 |
| GSE43922 | Up | 0.0118351636 |
| GSE24585 | Up | 0.1188760470 |
| GSE37065 | Down | -0.0192602425 |
| GSE28863_A1 | Down | -0.0346713848 |
| GSE28863_A2 | Up | 0.0240615224 |
| GSE28863_A3 | Up | 0.1105216939 |
| GSE28863_A4 | Down | -0.3232656843 |
| GSE48662 | Up | 0.0230917373 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016842 | Microarray | Functional MTI (Weak) | 18185580 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24755407 | We have recently described an Epigenetic-Senescence-Signature that facilitates prediction of the state of cellular aging by analysis of DNAm at six CpG sites (associated with the genes GRM7, CASR, PRAMEF2, SELP, CASP14 and KRTAP13-3), but this has not yet been proven over subsequent passages and with MSCs isolated under good manufacturing practice (GMP) conditions |
| 15301553 | Activation and substrate specificity of caspase-14 |
| 15301553 | We report that caspase-14, in contrast to other caspases, is not produced in active form following expression in Escherichia coli but can be activated by high concentrations of kosmotropic salts |
| 15301553 | We propose that caspase-14 requires proteolytic cleavage within the catalytic domain, followed by dimerization and ordering of mobile active site loops, to generate a competent enzyme |
| 15301553 | In the presence of kosmotropic salt, we were able to determine the substrate specificities of mouse and human caspase-14 |
| 15301553 | The results obtained with human caspase-14 classify this enzyme as a cytokine activator, but the mouse enzyme shows preferences similar to apical apoptotic caspases |
Entries Per Page
Displaying Page of
