HCSGD entry for FPR1
1. General information
| Official gene symbol | FPR1 |
|---|---|
| Entrez ID | 2357 |
| Gene full name | formyl peptide receptor 1 |
| Other gene symbols | FMLP FPR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004982 | N-formyl peptide receptor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005768 | Endosome | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006935 | Chemotaxis | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007188 | Adenylate cyclase-modulating G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007200 | Phospholipase C-activating G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007263 | Nitric oxide mediated signal transduction | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0050786 | RAGE receptor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4496667642 | 0.6919376581 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0916217819 |
| GSE13712_SHEAR | Up | 0.0144801225 |
| GSE13712_STATIC | Up | 0.0629871353 |
| GSE19018 | Up | 0.1439966348 |
| GSE19899_A1 | Up | 0.0241177109 |
| GSE19899_A2 | Up | 0.0775468998 |
| PubMed_21979375_A1 | Down | -0.1125199831 |
| PubMed_21979375_A2 | Up | 0.0256469198 |
| GSE35957 | Up | 0.0292286236 |
| GSE36640 | Up | 0.0305997357 |
| GSE54402 | Up | 0.1132111772 |
| GSE9593 | Up | 0.5690612041 |
| GSE43922 | Up | 0.1313647382 |
| GSE24585 | Up | 0.1196658388 |
| GSE37065 | Down | -0.0413929767 |
| GSE28863_A1 | Down | -0.0065897250 |
| GSE28863_A2 | Down | -0.1492006415 |
| GSE28863_A3 | Up | 0.0509107357 |
| GSE28863_A4 | Down | -0.1596015534 |
| GSE48662 | Up | 0.0936333601 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nedocromil | DB00716 | APRD01137 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018871 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 3651601 | The functions measured were superoxide generation and enzyme secretion (lysozyme and glucuronidase), following cell activation by either phorbol myristate acetate (PMA) or Formyl-methionyl-leucyl-phenylalanine (FMLP) |
| 3651601 | In addition we measured cytosolic calcium concentration and its increase following activation by FMLP |
| 3651601 | This applied to superoxide generation, basal and stimulated enzyme levels, and to basal cytosolic calcium concentration and its increase following activation by FMLP |
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