HCSGD entry for LPAR3
1. General information
| Official gene symbol | LPAR3 |
|---|---|
| Entrez ID | 23566 |
| Gene full name | lysophosphatidic acid receptor 3 |
| Other gene symbols | EDG7 Edg-7 GPCR HOFNH30 LP-A3 LPA3 RP4-678I3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IEA | biological_process |
| GO:0001965 | G-protein alpha-subunit binding | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005543 | Phospholipid binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008289 | Lipid binding | TAS | molecular_function |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0032060 | Bleb assembly | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0048672 | Positive regulation of collateral sprouting | IEA | biological_process |
| GO:0051482 | Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | IEA | biological_process |
| GO:0051928 | Positive regulation of calcium ion transport | IEA | biological_process |
| GO:0070915 | Lysophosphatidic acid receptor activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4616566050 | 0.4187556628 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1602845502 |
| GSE13712_SHEAR | Up | 0.1221900447 |
| GSE13712_STATIC | Down | -0.0690869982 |
| GSE19018 | Down | -0.0669566006 |
| GSE19899_A1 | Down | -0.2479909974 |
| GSE19899_A2 | Down | -0.4035014526 |
| PubMed_21979375_A1 | Up | 0.2654279710 |
| PubMed_21979375_A2 | Up | 0.0796300875 |
| GSE35957 | Up | 0.0962733672 |
| GSE36640 | Up | 1.0298398403 |
| GSE54402 | Down | -1.2135845205 |
| GSE9593 | Up | 0.0092903597 |
| GSE43922 | Up | 0.2358739412 |
| GSE24585 | Down | -0.1637544019 |
| GSE37065 | Down | -0.0048460961 |
| GSE28863_A1 | Down | -0.1307300483 |
| GSE28863_A2 | Down | -0.0028064462 |
| GSE28863_A3 | Up | 0.2022581890 |
| GSE28863_A4 | Up | 0.1729038880 |
| GSE48662 | Down | -0.0267096129 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12646237 | EDG-1 and EDG-4 were unchanged, but EDG-2 and EDG-7 were reduced with age |
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