HCSGD entry for FOSL2
1. General information
| Official gene symbol | FOSL2 |
|---|---|
| Entrez ID | 2355 |
| Gene full name | FOS-like antigen 2 |
| Other gene symbols | FRA2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0008219 | Cell death | TAS | biological_process |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0032570 | Response to progesterone | IEA | biological_process |
| GO:0032870 | Cellular response to hormone stimulus | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043278 | Response to morphine | IEA | biological_process |
| GO:0048146 | Positive regulation of fibroblast proliferation | IEA | biological_process |
| GO:0051412 | Response to corticosterone | IEA | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3306140838 | 0.0144200144 | 0.9999902473 | 0.2358247205 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8280462920 |
| GSE13712_SHEAR | Up | 0.2160408458 |
| GSE13712_STATIC | Up | 0.0168557899 |
| GSE19018 | Up | 0.4059017515 |
| GSE19899_A1 | Down | -0.7497023990 |
| GSE19899_A2 | Down | -0.3147098009 |
| PubMed_21979375_A1 | Down | -0.4228633965 |
| PubMed_21979375_A2 | Down | -0.5834518018 |
| GSE35957 | Down | -0.4995732488 |
| GSE36640 | Down | -1.4536032495 |
| GSE54402 | Down | -0.4393720273 |
| GSE9593 | Down | -0.2130967378 |
| GSE43922 | Down | -0.6043250316 |
| GSE24585 | Up | 0.0261158504 |
| GSE37065 | Down | -0.2150283526 |
| GSE28863_A1 | Up | 0.9089410598 |
| GSE28863_A2 | Up | 0.7872955973 |
| GSE28863_A3 | Up | 0.0473778744 |
| GSE28863_A4 | Down | -0.3347208330 |
| GSE48662 | Up | 1.0681883405 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-342-3p | MIMAT0000753 | MIRT043735 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048624 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21507983 | The inhibition of Fra-2 had no visible phenotype in normal CEF but caused the appearance of lipid-rich vesicles in v-Src-transformed CEF |
| 15946240 | This EGF-induced Fra-2 phosphorylation was attenuated in senescent cells |
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