HCSGD entry for FOS

1. General information

Official gene symbolFOS
Entrez ID2353
Gene full nameFBJ murine osteosarcoma viral oncogene homolog
Other gene symbolsAP-1 C-FOS p55
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001661Conditioned taste aversionIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006306DNA methylationTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0009409Response to coldIEAbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009629Response to gravityIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030431SleepIEAbiological_process
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0034614Cellular response to reactive oxygen speciesIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045672Positive regulation of osteoclast differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0071277Cellular response to calcium ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00139527370.01399340070.10089285710.2325254419

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.8436024018
GSE13712_SHEARDown-0.2162786527
GSE13712_STATICUp1.0064539676
GSE19018Down-2.8997932463
GSE19899_A1Up0.3135358926
GSE19899_A2Up0.6512380170
PubMed_21979375_A1Up1.0227359829
PubMed_21979375_A2Up1.2194566963
GSE35957Up0.6591788033
GSE36640Down-0.2574011374
GSE54402Up0.3775308832
GSE9593Down-2.1895278592
GSE43922Up0.0680064628
GSE24585Up1.3007802252
GSE37065Up0.1965301979
GSE28863_A1Up1.7332224443
GSE28863_A2Down-0.5043829002
GSE28863_A3Down-0.8713956431
GSE28863_A4Up0.8748154115
GSE48662Up0.5346578751

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NadroparinDB08813 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-101-3pMIMAT0000099MIRT001219Western blotNon-Functional MTI19008416
hsa-miR-101-3pMIMAT0000099MIRT001219qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133651
hsa-miR-101-3pMIMAT0000099MIRT001219qRT-PCRFunctional MTI (Weak)20712078
hsa-miR-221-3pMIMAT0000278MIRT004484qRT-PCR//Luciferase reporter assay//Western blot//Northern blotFunctional MTI20299489
hsa-miR-221-3pMIMAT0000278MIRT004484Luciferase reporter assayFunctional MTI23400877
hsa-miR-222-3pMIMAT0000279MIRT004485qRT-PCR//Luciferase reporter assay//Western blot//Northern blotFunctional MTI20299489
hsa-miR-222-3pMIMAT0000279MIRT004485Luciferase reporter assayFunctional MTI23400877
hsa-miR-181a-5pMIMAT0000256MIRT006851Luciferase reporter assayFunctional MTI22956783
hsa-miR-139-5pMIMAT0000250MIRT006976qRT-PCR//Western blotFunctional MTI23001723
hsa-miR-29b-3pMIMAT0000100MIRT007254Western blotFunctional MTI23254643
hsa-miR-335-5pMIMAT0000765MIRT019187MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024954MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026898MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-221-3pMIMAT00002781hsa-miR-22120299489
hsa-miR-222-3pMIMAT00002791hsa-miR-22220299489
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27127888Only PLAU, JUN, and FOS were related to DNA damage, telomere dysfunction-induced aging markers, neutrophil function and IgA nephropathy
25945449RESULTS: Different transcriptional profiles were observed in young, pre-senescent and senescent HDFs, in which cellular aging increased AKT, FOXO3, CDKN1A and RSK1 mRNA expression level, but decreased ELK1, FOS and SIRT1 mRNA expression level
25945449The three down-regulated mRNA in cellular aging, ELK1, FOS and SIRT1, were increased with tocotrienol-rich fraction treatment
23185405We have also quantified the transcripts of genes involved in the repair of oxidative DNA damage at telomeres (OGG1), telomere regulation and elongation (TERT), and in the response to biopsychological stress (FOS and DUSP1)
7525690C-fos is an immediate-early gene that is induced by external stimuli and is possibly involved in initiation of DNA synthesis by such stimuli
7908266DNA synthesis and Fos and Jun protein expression in mitotic and postmitotic WI-38 fibroblasts in vitro
7908266DNA synthesis of mitotic and postmitotic WI-38 cell populations may be regulated by the expression of Fos and Jun proteins
7908266The Fos level of MFs was higher by a factor of 15-24 and the Jun level of MFs by a factor of 4
1409718Induction of cyclin gene expression by serum is reduced concomitantly with the decline in FOS induction in aging HDFs, suggesting a possible relationship to the decrease in the proliferative response to mitogens during cellular senescence
1297331We find that cyclin A and p34cdc2 expression is decreased by two- to four-fold in old fibroblasts, but that Fos expression and binding activity are reduced by as much as 95% in old, as opposed to young cells, despite equivalent amounts of p105Rb and Jun proteins being expressed
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