HCSGD entry for CLCF1
1. General information
| Official gene symbol | CLCF1 |
|---|---|
| Entrez ID | 23529 |
| Gene full name | cardiotrophin-like cytokine factor 1 |
| Other gene symbols | BSF-3 BSF3 CISS2 CLC NNT-1 NNT1 NR6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002639 | Positive regulation of immunoglobulin production | ISS | biological_process |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005125 | Cytokine activity | IDA NAS | molecular_function |
| GO:0005127 | Ciliary neurotrophic factor receptor binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IDA NAS | cellular_component |
| GO:0007166 | Cell surface receptor signaling pathway | ISS | biological_process |
| GO:0007259 | JAK-STAT cascade | ISS | biological_process |
| GO:0008083 | Growth factor activity | TAS | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | NAS | biological_process |
| GO:0030183 | B cell differentiation | ISS | biological_process |
| GO:0030890 | Positive regulation of B cell proliferation | ISS | biological_process |
| GO:0042517 | Positive regulation of tyrosine phosphorylation of Stat3 protein | IDA TAS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0048295 | Positive regulation of isotype switching to IgE isotypes | ISS | biological_process |
| GO:0048711 | Positive regulation of astrocyte differentiation | ISS | biological_process |
| GO:0097058 | CRLF-CLCF1 complex | IDA | cellular_component |
| GO:0097059 | CNTFR-CLCF1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0249057483 | 0.3562074845 | 0.3720187181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1320555513 |
| GSE13712_SHEAR | Up | 0.0214467375 |
| GSE13712_STATIC | Down | -0.1528500643 |
| GSE19018 | Down | -0.6680477523 |
| GSE19899_A1 | Up | 0.3241602518 |
| GSE19899_A2 | Up | 1.4051063844 |
| PubMed_21979375_A1 | Up | 3.4737264871 |
| PubMed_21979375_A2 | Up | 0.9193763728 |
| GSE35957 | Down | -0.6021750908 |
| GSE36640 | Up | 0.1309969624 |
| GSE54402 | Up | 0.7245745749 |
| GSE9593 | Down | -0.5360654184 |
| GSE43922 | Up | 0.5491605576 |
| GSE24585 | Down | -0.1416481512 |
| GSE37065 | Up | 0.0916128172 |
| GSE28863_A1 | Down | -0.1792789696 |
| GSE28863_A2 | Down | -0.1117573085 |
| GSE28863_A3 | Up | 0.0810329205 |
| GSE28863_A4 | Up | 0.0341214926 |
| GSE48662 | Up | 0.0619893251 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15034937 | The additional findings of its influence on NNT1 and p48ZnF (new-neurotrophin-1, p48-zinc-finger-protein)-signaling and its down-regulation in the brain of AD subjects point to a possible pivotal role of p60TRP in the control of cellular aging and survival |
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