HCSGD entry for MORC3
1. General information
| Official gene symbol | MORC3 |
|---|---|
| Entrez ID | 23515 |
| Gene full name | MORC family CW-type zinc finger 3 |
| Other gene symbols | NXP2 ZCW5 ZCWCC3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007569 | Cell aging | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0016235 | Aggresome | IDA | cellular_component |
| GO:0016605 | PML body | IDA IEA | cellular_component |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0048147 | Negative regulation of fibroblast proliferation | IDA | biological_process |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0051457 | Maintenance of protein location in nucleus | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0201053987 | 0.8487975951 | 0.3420940722 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0145597681 |
| GSE13712_SHEAR | Up | 0.1789261910 |
| GSE13712_STATIC | Down | -0.0038878899 |
| GSE19018 | Up | 0.1881448338 |
| GSE19899_A1 | Up | 0.8504786830 |
| GSE19899_A2 | Up | 0.6028211913 |
| PubMed_21979375_A1 | Up | 1.2521995265 |
| PubMed_21979375_A2 | Up | 0.4206408168 |
| GSE35957 | Down | -0.1904653369 |
| GSE36640 | Up | 0.1006612643 |
| GSE54402 | Up | 0.6642961746 |
| GSE9593 | Up | 0.1083132466 |
| GSE43922 | Up | 0.2900969652 |
| GSE24585 | Up | 0.4901766257 |
| GSE37065 | Up | 0.4874535819 |
| GSE28863_A1 | Down | -0.1228327461 |
| GSE28863_A2 | Up | 0.0667769863 |
| GSE28863_A3 | Down | -0.9596500556 |
| GSE28863_A4 | Up | 0.0806997769 |
| GSE48662 | Down | -0.2277752709 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020644 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027287 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028275 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030797 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048085 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27188231 | Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation |
| 27188231 | Morc3, a member of a highly conserved nuclear matrix protein super-family plays an important part in chromatin remodeling, DNA repair, epigenetic regulation and cellular senescence |
| 27188231 | Strikingly, Morc3 protein localization within the nuclear membrane was shifted to the cytoplasm in Morc3(mut +/-) osteoclasts |
| 27188231 | Collectively, our data show that Morc3 is a previously unreported regulator of cortical bone homeostasis and haematopoietic stem cells niche, accompanied by altered bone cell differentiation |
| 20501696 | Two-step colocalization of MORC3 with PML nuclear bodies |
| 20501696 | MORC3 (microrchidia family CW-type zinc-finger 3), also known as NXP2, which consists of GHL-ATPase, a CW-type zinc-finger and coiled-coil domains, is localized in PML NBs, where it recruits and activates p53 to induce cellular senescence |
| 20501696 | Interestingly, we found that MORC3 can form PML-independent nuclear domains (NDs) in mouse hematopoietic cells and even in Pml-deficient cells |
| 20501696 | Here, we show that MORC3 colocalizes with PML by a two-step molecular mechanism: the PML-independent formation of MORC3 NDs by the ATPase cycle, and the association of MORC3 with PML via the SUMO1-SUMO-interacting motif (SIM) |
| 20501696 | Similarly to other members of the GHL-ATPase family, MORC3 functions as a 'molecular clamp' |
| 20501696 | ATP binding induces conformational changes in MORC3, leading to the formation of MORC3 NDs, and subsequent ATP hydrolysis mediates the diffusion and binding of MORC3 to the nuclear matrix |
| 20501696 | MORC3 might clamp DNA or nucleosomes in MORC3 NDs via the CW domain |
| 20501696 | Furthermore, the SUMOylation of MORC3 at five sites was involved in the association of MORC3 with PML, and SUMO1-unmodified MORC3 formed NDs independently of PML |
| 17332504 | Dynamic regulation of p53 subnuclear localization and senescence by MORC3 |
| 17332504 | Here we found that MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal human and mouse fibroblasts but not p53-/- fibroblasts |
| 17332504 | Conversely, genotoxic stress-induced phosphorylation and stabilization of p53 but barely increased its transcriptional activity in Morc3-/- fibroblasts |
| 17332504 | These results suggest that MORC3 regulates p53 activity and localization into PML-NBs |
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