HCSGD entry for HEY2

1. General information

Official gene symbolHEY2
Entrez ID23493
Gene full namehairy/enhancer-of-split related with YRPW motif 2
Other gene symbolsCHF1 GRIDLOCK GRL HERP1 HESR2 HRT2 bHLHb32
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityIEA ISSmolecular_function
GO:0000988Protein binding transcription factor activityIDA IEAmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001570VasculogenesisIEA ISSbiological_process
GO:0003150Muscular septum morphogenesisIEA ISSbiological_process
GO:0003151Outflow tract morphogenesisIEA ISSbiological_process
GO:0003171Atrioventricular valve developmentIEAbiological_process
GO:0003184Pulmonary valve morphogenesisIEA ISSbiological_process
GO:0003186Tricuspid valve morphogenesisISSbiological_process
GO:0003195Tricuspid valve formationIEAbiological_process
GO:0003199Endocardial cushion to mesenchymal transition involved in heart valve formationIEAbiological_process
GO:0003208Cardiac ventricle morphogenesisISSbiological_process
GO:0003214Cardiac left ventricle morphogenesisIEA ISSbiological_process
GO:0003215Cardiac right ventricle morphogenesisIEA ISSbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007219Notch signaling pathwayIEA ISS TASbiological_process
GO:0008134Transcription factor bindingIEA NASmolecular_function
GO:0009948Anterior/posterior axis specificationIEAbiological_process
GO:0010460Positive regulation of heart rateIEAbiological_process
GO:0010621Negative regulation of transcription by transcription factor localizationISSbiological_process
GO:0010629Negative regulation of gene expressionISSbiological_process
GO:0010667Negative regulation of cardiac muscle cell apoptotic processIEAbiological_process
GO:0014031Mesenchymal cell developmentISSbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0016580Sin3 complexIDAcellular_component
GO:0017053Transcriptional repressor complexIDAcellular_component
GO:0035910Ascending aorta morphogenesisIEA ISSbiological_process
GO:0035912Dorsal aorta morphogenesisIEA ISSbiological_process
GO:0035939Microsatellite bindingIDA IEAmolecular_function
GO:0036304Umbilical cord morphogenesisIEA ISSbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045165Cell fate commitmentIEAbiological_process
GO:0045607Regulation of auditory receptor cell differentiationIEAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0051145Smooth muscle cell differentiationNASbiological_process
GO:0055015Ventricular cardiac muscle cell developmentIEA ISSbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionISSbiological_process
GO:0060347Heart trabecula formationIEAbiological_process
GO:0060411Cardiac septum morphogenesisISSbiological_process
GO:0060412Ventricular septum morphogenesisISSbiological_process
GO:0060413Atrial septum morphogenesisIEA ISSbiological_process
GO:0060633Negative regulation of transcription initiation from RNA polymerase II promoterIDAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEA ISSbiological_process
GO:0060842Arterial endothelial cell differentiationIEA ISSbiological_process
GO:0060948Cardiac vascular smooth muscle cell developmentIEAbiological_process
GO:0060977Coronary vasculature morphogenesisIEAbiological_process
GO:0061156Pulmonary artery morphogenesisIEA ISSbiological_process
GO:0061314Notch signaling involved in heart developmentICbiological_process
GO:0065004Protein-DNA complex assemblyIEAbiological_process
GO:0090102Cochlea developmentIEAbiological_process
GO:0097084Vascular smooth muscle cell developmentIEPbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIDA IEAbiological_process
GO:2000723Negative regulation of cardiac vascular smooth muscle cell differentiationISSbiological_process
GO:2000820Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIEA ISSbiological_process
GO:2001212Regulation of vasculogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63501572510.29248748910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0990925013
GSE13712_SHEARDown-0.6470126624
GSE13712_STATICDown-0.0802939023
GSE19018Down-0.0031688013
GSE19899_A1Up0.1152145216
GSE19899_A2Up0.0929770649
PubMed_21979375_A1Down-0.0336300906
PubMed_21979375_A2Up0.0521822937
GSE35957Down-0.2472909981
GSE36640Up0.0724320016
GSE54402Down-0.0134494081
GSE9593Down-0.0983807567
GSE43922Up0.0188993242
GSE24585Up0.2483769242
GSE37065Down-0.5237322137
GSE28863_A1Up0.0039705520
GSE28863_A2Down-0.0838754203
GSE28863_A3Up0.0425289781
GSE28863_A4Up0.0235380912
GSE48662Down-0.0424982631

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019456MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT022041MicroarrayFunctional MTI (Weak)17612493
hsa-miR-181a-5pMIMAT0000256MIRT025160MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.