HCSGD entry for CBX7
1. General information
| Official gene symbol | CBX7 |
|---|---|
| Entrez ID | 23492 |
| Gene full name | chromobox homolog 7 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003727 | Single-stranded RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0035064 | Methylated histone residue binding | IEA | molecular_function |
| GO:0035102 | PRC1 complex | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0727819346 | 0.7022085977 | 0.5749379652 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1831466629 |
| GSE13712_SHEAR | Down | -0.0672526727 |
| GSE13712_STATIC | Up | 0.0408564378 |
| GSE19018 | Up | 0.5039420907 |
| GSE19899_A1 | Down | -0.0828414853 |
| GSE19899_A2 | Down | -0.0183265894 |
| PubMed_21979375_A1 | Down | -0.3516027599 |
| PubMed_21979375_A2 | Up | 0.0555872962 |
| GSE35957 | Up | 0.6995564513 |
| GSE36640 | Up | 0.9610688591 |
| GSE54402 | Down | -0.1888934801 |
| GSE9593 | Up | 0.6675126680 |
| GSE43922 | Up | 0.0487163684 |
| GSE24585 | Up | 0.2648092879 |
| GSE37065 | Up | 0.0228154609 |
| GSE28863_A1 | Down | -0.0009935993 |
| GSE28863_A2 | Down | -0.0362996273 |
| GSE28863_A3 | Up | 0.0804651388 |
| GSE28863_A4 | Down | -0.0079416151 |
| GSE48662 | Up | 0.7568039904 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181b-5p | MIMAT0000257 | MIRT006371 | Luciferase reporter assay | Functional MTI | 21779448 |
| hsa-miR-421 | MIMAT0003339 | MIRT001104 | qRT-PCR//Western blot | Functional MTI | 19802518 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039038 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 | |||
| hsa-miR-421 | MIMAT0003339 | NA | hsa-miR-421 | {Western blot} | {downregulation} | 19802518 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25328137 | In a screen for transcription factors regulating the expression of the polycomb protein CBX7, we identified NR2E1 as one of its more prominent regulators |
| 25328137 | NR2E1 binds at the CBX7 promoter, inducing its expression |
| 25328137 | Notably CBX7 represses NR2E1 as part of a regulatory loop |
| 25328137 | We also confirmed that NR2E1 regulates CBX7 and restrains senescence in NSCs |
| 25328137 | Finally, we observed that the expression of NR2E1 directly correlates with that of CBX7 in human glioblastoma multiforme |
| 24217920 | We show that SA-miRNAs-26b, 181a, 210 and 424 function in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm development (EED), enhancer of zeste homologue 2 (EZH2) and suppressor of zeste 12 homologue (Suz12), thereby activating p16 |
| 20723236 | Oncogenic role of the chromobox protein CBX7 in gastric cancer |
| 20723236 | BACKGROUND: Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus |
| 20723236 | It was found that CBX7 expression was upregulated in lymphoma, but downregulated in some other human malignancies |
| 20723236 | The role of CBX7 in most types of cancer is still not clear |
| 20723236 | The purpose of this study is to investigate the role of CBX7 in gastric cancer |
| 20723236 | METHODS: The expression of CBX7 and its potential target protein p16(INK4a) in gastric cancer cell lines and gastric tumors was assayed by Western blot analysis and immunohistochemistry(IHC) |
| 20723236 | The correlations between CBX7 expression and p16(INK4a), clinicopathological characteristics, and prognosis were analyzed |
| 20723236 | Gastric cancer cell line SGC-7901 was transfected with CBX7 siRNA expressing plasmids, and the expression of various proteins was analyzed by Western blot analysis |
| 20723236 | Cellular senescence, anchorage independent growth, and cell migration assays were performed to determine the functional role of CBX7 in gastric cancer cells |
| 20723236 | RESULTS: CBX7 was found to be overexpressed in gastric cancer cell lines and gastric tumors |
| 20723236 | Overexpression of CBX7 in gastric cancer tissues correlated with patients' age, clinical stage and lymph node metastasis |
| 20723236 | Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a) |
| 20723236 | CONCLUSIONS: CBX7 acts as an oncogene in the carcinogenesis and progression of gastric cancer, and it may regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway |
| 19636380 | Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 and BMI1 |
| 19636380 | In primary human fibroblasts, CBX7, CBX8, MEL18 and BMI1 are present at the INK4a locus and shRNA-mediated knockdown of any one of these components results in de-repression of INK4a and proliferative arrest |
| 19636380 | Sequential chromatin immunoprecipitation (ChIP) reveals that CBX7 and CBX8 bind simultaneously to the same region of chromatin and knockdown of one of the Pc or Psc proteins results in release of the other, suggesting that the binding of PRC1 complexes is interdependent |
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