HCSGD entry for SF3B1
1. General information
| Official gene symbol | SF3B1 |
|---|---|
| Entrez ID | 23451 |
| Gene full name | splicing factor 3b, subunit 1, 155kDa |
| Other gene symbols | Hsh155 MDS PRP10 PRPF10 SAP155 SF3b155 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000375 | RNA splicing, via transesterification reactions | NAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC NAS TAS | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | NAS | cellular_component |
| GO:0005689 | U12-type spliceosomal complex | IDA | cellular_component |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3172716842 | 0.8183528741 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0350485606 |
| GSE13712_SHEAR | Down | -0.1866720207 |
| GSE13712_STATIC | Down | -0.3227970035 |
| GSE19018 | Up | 0.3779547411 |
| GSE19899_A1 | Down | -0.0142794775 |
| GSE19899_A2 | Up | 0.3860906182 |
| PubMed_21979375_A1 | Up | 0.2333957293 |
| PubMed_21979375_A2 | Up | 0.5159548646 |
| GSE35957 | Down | -0.1504085300 |
| GSE36640 | Down | -0.3045222486 |
| GSE54402 | Down | -0.0449827810 |
| GSE9593 | Down | -0.2047467864 |
| GSE43922 | Up | 0.0460881704 |
| GSE24585 | Up | 0.1976484641 |
| GSE37065 | Up | 0.0583057284 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.6623363267 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040227 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-504-5p | MIMAT0002875 | MIRT041092 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042496 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052156 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052776 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27147278 | Prominent examples include aberrations in cytokines and their signaling pathways (such as tumor necrosis factor-alpha, interferon-gamma, SMAD proteins), mutations in genes encoding the RNA splicing machinery (SF3B1, SRSF2, ZRSR2, and U2AF1 genes), mutations in genes disrupting the epigenetic machinery (TET2, DNMT3A, DNMT3B, EZH2, ASXL1) |
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