HCSGD entry for SF3B3
1. General information
| Official gene symbol | SF3B3 |
|---|---|
| Entrez ID | 23450 |
| Gene full name | splicing factor 3b, subunit 3, 130kDa |
| Other gene symbols | RSE1 SAP130 SF3b130 STAF130 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | TAS | cellular_component |
| GO:0005689 | U12-type spliceosomal complex | IDA | cellular_component |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030532 | Small nuclear ribonucleoprotein complex | TAS | cellular_component |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2400755404 | 0.3149842711 | 0.9260006301 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1243047988 |
| GSE13712_SHEAR | Down | -0.0492710352 |
| GSE13712_STATIC | Up | 0.2642106165 |
| GSE19018 | Down | -0.3747138796 |
| GSE19899_A1 | Down | -0.3392900213 |
| GSE19899_A2 | Up | 0.0695268175 |
| PubMed_21979375_A1 | Up | 0.1257007460 |
| PubMed_21979375_A2 | Up | 0.3682894728 |
| GSE35957 | Down | -0.5413573359 |
| GSE36640 | Down | -0.4620970383 |
| GSE54402 | Up | 0.1238033068 |
| GSE9593 | Up | 0.2124622674 |
| GSE43922 | Down | -0.0982991337 |
| GSE24585 | Up | 0.0354355240 |
| GSE37065 | Down | -0.2449732895 |
| GSE28863_A1 | Up | 0.6836101562 |
| GSE28863_A2 | Up | 0.6426987750 |
| GSE28863_A3 | Down | -0.5554554294 |
| GSE28863_A4 | Up | 0.1611415178 |
| GSE48662 | Up | 0.3215484774 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028585 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029634 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038171 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039913 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041126 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041279 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041733 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042599 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042941 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043737 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044771 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046492 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046744 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046961 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047659 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048571 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049223 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-3p | MIMAT0000088 | MIRT049912 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051145 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
