HCSGD entry for FNTB

1. General information

Official gene symbolFNTB
Entrez ID2342
Gene full namefarnesyltransferase, CAAX box, beta
Other gene symbolsFPTB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004311Farnesyltranstransferase activityIEAmolecular_function
GO:0004660Protein farnesyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005875Microtubule associated complexIDAcellular_component
GO:0005965Protein farnesyltransferase complexIDAcellular_component
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0010035Response to inorganic substanceIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016056Rhodopsin mediated signaling pathwayTASbiological_process
GO:0018343Protein farnesylationIDAbiological_process
GO:0022400Regulation of rhodopsin mediated signaling pathwayTASbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIEAbiological_process
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27386333350.79457001630.97027131901.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1136732300
GSE13712_SHEARUp0.2248337314
GSE13712_STATICUp0.1732896729
GSE19018Up0.0041407040
GSE19899_A1Up0.0663868073
GSE19899_A2Up0.9032332380
PubMed_21979375_A1Up0.6612441823
PubMed_21979375_A2Up0.4267565347
GSE35957Down-0.5621525641
GSE36640Up0.0145788085
GSE54402Down-0.0902927399
GSE9593Up0.1147818233
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0769329826
GSE28863_A2Up0.1083111052
GSE28863_A3Down-0.3618751505
GSE28863_A4Down-0.0419824815
GSE48662Up0.0096059277

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AZD3409DB04893 -
TipifarnibDB04960 -
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILEDB06953 -
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINEDB07216 -
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILEDB07227 -
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDDB07771 -
FARNESYL DIPHOSPHATEDB07780 -
GERANYLGERANYL DIPHOSPHATEDB07841 -
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDDB07895 -
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILEDB08674 -
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILEDB08676 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT004223MicroarrayFunctional MTI (Weak)16822819
hsa-miR-24-3pMIMAT0000080MIRT030444MicroarrayFunctional MTI (Weak)19748357
hsa-miR-183-5pMIMAT0000261MIRT047154CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.