HCSGD entry for SIRT3
1. General information
| Official gene symbol | SIRT3 |
|---|---|
| Entrez ID | 23410 |
| Gene full name | sirtuin 3 |
| Other gene symbols | SIR2L3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0006471 | Protein ADP-ribosylation | TAS | biological_process |
| GO:0006476 | Protein deacetylation | IDA IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA IEA | molecular_function |
| GO:0009060 | Aerobic respiration | IMP | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016811 | Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | IEA | molecular_function |
| GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | IEA | molecular_function |
| GO:0034983 | Peptidyl-lysine deacetylation | IMP | biological_process |
| GO:0070403 | NAD+ binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8464117853 | 0.1843830819 | 0.9999902473 | 0.8327415337 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0689829069 |
| GSE13712_SHEAR | Down | -0.4281009106 |
| GSE13712_STATIC | Down | -0.3240463736 |
| GSE19018 | Up | 0.2378396849 |
| GSE19899_A1 | Down | -0.1521905590 |
| GSE19899_A2 | Down | -0.3325475523 |
| PubMed_21979375_A1 | Down | -0.2250699255 |
| PubMed_21979375_A2 | Down | -0.3022490951 |
| GSE35957 | Up | 0.0699160223 |
| GSE36640 | Up | 0.0137105825 |
| GSE54402 | Down | -0.2888245529 |
| GSE9593 | Up | 0.0713660343 |
| GSE43922 | Down | -0.4585995355 |
| GSE24585 | Up | 0.3369396027 |
| GSE37065 | Down | -0.1109708094 |
| GSE28863_A1 | Up | 0.1807656809 |
| GSE28863_A2 | Up | 0.0882872606 |
| GSE28863_A3 | Down | -0.1819985085 |
| GSE28863_A4 | Up | 0.0690062458 |
| GSE48662 | Up | 0.3870286825 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-5-Diphosphoribose | DB02059 | EXPT00544 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26948035 | SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear |
| 26948035 | Previous mechanistic studies have revealed in detail that SIRT1, SIRT3, and SIRT6 show protective functions against vascular aging, and definite vascular function of other SIRTs is under investigation |
| 26141949 | CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance |
| 26141949 | SIRT3, a member of the sirtuin family of NAD(+)-dependent protein deacetylases in mitochondria, promotes metabolic homeostasis through regulation of mitochondrial protein deacetylation and plays a key role in prevention of cell aging |
| 26141949 | SIRT3 transcriptional activation is due to SIRT3 promoter activation controlled by the stress transcription factor NF-kappaB |
| 26141949 | Posttranscriptionally, SIRT3 enzymatic activity is further enhanced via Thr150/Ser159 phosphorylation by cyclin B1-CDK1, which is also induced by radiation and relocated to mitochondria together with SIRT3 |
| 26141949 | Cells expressing Thr150Ala/Ser159Ala-mutant SIRT3 show a reduction in mitochondrial protein lysine deacetylation, Deltapsim, MnSOD activity, and mitochondrial ATP generation |
| 26141949 | Tumors harboring Thr150Ala/Ser159Ala-mutant SIRT3 show inhibited growth and increased sensitivity to in vivo local irradiation |
| 26141949 | These results demonstrate that enhanced SIRT3 transcription and posttranslational modifications in mitochondria contribute to adaptive radioresistance in tumor cells |
| 26141949 | CDK1-mediated SIRT3 phosphorylation is a potential effective target to sensitize tumor cells to radiotherapy |
| 26121691 | SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells |
| 26121691 | SIRT3 is a key NAD+-dependent protein deacetylase in the mitochondria of mammalian cells, functioning to prevent cell aging and transformation via regulation of mitochondrial metabolic homeostasis |
| 26121691 | However, SIRT3 is also found to express in some human tumors; its role in these SIRT3-expressing tumor cells needs to be elucidated |
| 26121691 | This study demonstrated that the expression of SIRT3 was elevated in a group of gastric cancer cells compared to normal gastric epithelial cells |
| 26121691 | Although SIRT3 expression levels were increased in the gastric tumor tissues compared to the adjacent non-tumor tissues, SIRT3 positive cancer cells were more frequently detected in the intestinal type gastric cancers than the diffuse type gastric cancers, indicating that SIRT3 is linked with subtypes of gastric cancer |
| 26121691 | Overexpression of SIRT3 promoted cell proliferation and enhanced ATP generation, glucose uptake, glycogen formation, MnSOD activity and lactate production, which were inhibited by SIRT3 knockdown, indicating that SIRT3 plays a role in reprogramming the bioenergetics in gastric tumor cells |
| 26121691 | Further analysis revealed that SIRT3 interacted with and deacetylated the lactate dehydrogenase A (LDHA), a key protein in regulating anaerobic glycolysis, enhancing LDHA activity |
| 26121691 | Thus, in addition to the well-documented SIRT3-mediated mitochondrial homeostasis in normal cells, SIRT3 may enhance glycolysis and cell proliferation in SIRT3-expressing cancer cells |
| 26112889 | This review focuses on the cardiovascular effects of Sirt1, Sirt3, Sirt6, and Sirt7 |
| 26112889 | Sirt3 provides beneficial effects in the context of left ventricular hypertrophy, cardiomyopathy, oxidative stress, metabolic homeostasis, and dyslipidaemia |
| 25192254 | Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction |
| 25192254 | Sirtuin-3 (Sirt3) has a critical role in the regulation of human aging and reactive oxygen species (ROS) formation |
| 25192254 | A recent study has identified Sirt3 as an essential regulator of stem cell aging |
| 25192254 | This study investigated whether Sirt3 is necessary for bone marrow cell (BMC)-mediated cardiac repair in post-myocardial infarction (MI) |
| 25192254 | In vivo, WT and Sirt3 KO mice were subjected to MI and BMCs from WT and Sirt3 KO mice were injected into ischemic area immediately |
| 25192254 | Loss of Sirt3 further enhanced ROS formation and apoptosis in EPCs |
| 25192254 | Overexpression of Sirt3 or treatment with NADPH oxidase inhibitor apocynin (Apo, 200 and 400 microM) rescued these abnormalities |
| 25192254 | Our data demonstrate that Sirt3 is essential for BMC therapy; and loss of Sirt3 limits BMC-mediated angiogenesis and cardiac repair in post-MI |
| 24697269 | 3-fold selectivity for SIRT3 versus SIRT1 and SIRT2, respectively |
| 23997094 | Similarly, sirtuin expression was relatively well-preserved in aorta from both genotypes, whereas expression of SIRT1, SIRT2, SIRT3, SIRT4, and SIRT6 were significantly reduced in the aortic valve |
| 23494737 | SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway |
| 23494737 | Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene |
| 23494737 | SIRT3 is the only sirtuin reported to be associated with human life span |
| 23494737 | Many recent studies have indicated that SIRT3 levels are elevated by exercise and caloric restriction, but whether SIRT3 influences cell senescence under stressed conditions in human diploid fibroblasts has not been established |
| 23494737 | Our data showed that expression of SIRT3 is elevated in human diploid fibroblasts under low glucose (3 |
| 23494737 | We have demonstrated that SIRT3 interacts with forkhead box protein O1 (FOXO1) |
| 23494737 | We have demonstrated that overexpression of SIRT3 under high glucose conditions reduces FOXO1 acetylation, suggesting that deacetylation of FOXO1 by SIRT3 elevates the expression of the FOXO1 target genes, catalase, and manganese superoxide dismutase (MnSOD) while decreasing senescence phenotypes |
| 23494737 | We studied the effects of SIRT3 protein knockdown by shRNA under low glucose conditions |
| 23494737 | These results demonstrate for the first time that SIRT3 overexpression antagonizes high glucose-induced cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway |
| 23488583 | Forced expression of SIRT3, which activates the reactive oxygen species (ROS) scavenger superoxide dismutase 2 (SOD2) by de-acetylation to reduce oxidative stress, functionally rejuvenates mouse HSCs |
| 23488583 | It is likely that ectopic expression of SIRT3 restores homeostasis in gene expression networks sensitive to oxidative stress |
| 23488583 | The effect of up-regulated SIRT3 in HSCs is one of first examples in which intrinsic cellular aging, not apparently associated with changes in the micro-environment, was reversed |
| 23488583 | However, the stability of rejuvenation in the absence of continued supplemental SIRT3 expression was not investigated |
| 22283774 | Activation of the classic RAS, ACE/Ang II/AT1R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions |
| 20463968 | In order to address the role of p53 in navigating cellular senescence through the mitochondria, we identified SirT3 to rescue EJ/p53 cells from induced p53-mediated growth arrest |
| 20463968 | Human SirT3 function appears coupled with p53 early during the initiation of p53 expression in the mitochondria by biochemical and cellular localization analysis |
| 20463968 | Our evidence suggests that SirT3 partially abrogates p53 activity to enact growth arrest and senescence |
| 20463968 | Additionally, we identified the chaperone protein BAG-2 in averting SirT3 targeting of p53 -mediated senescence |
| 20463968 | These studies identify a complex relationship between p53, SirT3, and chaperoning factor BAG-2 that may link the salvaging and quality assurance of the p53 protein for control of cellular fate independent of transcriptional activity |
| 17003781 | Increased levels of SIRT3 and SIRT7 transcription were also associated with node-positive breast cancer (P<0 |
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