HCSGD entry for SIRT4
1. General information
| Official gene symbol | SIRT4 |
|---|---|
| Entrez ID | 23409 |
| Gene full name | sirtuin 4 |
| Other gene symbols | SIR2L4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0006342 | Chromatin silencing | TAS | biological_process |
| GO:0006471 | Protein ADP-ribosylation | IEA ISS TAS | biological_process |
| GO:0006541 | Glutamine metabolic process | IEA ISS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA ISS | biological_process |
| GO:0034979 | NAD-dependent protein deacetylase activity | IDA IEA | molecular_function |
| GO:0034983 | Peptidyl-lysine deacetylation | IEA ISS | biological_process |
| GO:0046322 | Negative regulation of fatty acid oxidation | IEA ISS | biological_process |
| GO:0046676 | Negative regulation of insulin secretion | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046889 | Positive regulation of lipid biosynthetic process | IEA ISS | biological_process |
| GO:0070403 | NAD+ binding | IEA | molecular_function |
| GO:0072350 | Tricarboxylic acid metabolic process | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0123146271 | 0.9714385206 | 0.2772739949 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1504487105 |
| GSE13712_SHEAR | Up | 0.3247842079 |
| GSE13712_STATIC | Up | 0.0033373771 |
| GSE19018 | Down | -0.0910786706 |
| GSE19899_A1 | Up | 0.3137068207 |
| GSE19899_A2 | Up | 0.9841992298 |
| PubMed_21979375_A1 | Up | 1.8369567756 |
| PubMed_21979375_A2 | Up | 0.7791986435 |
| GSE35957 | Up | 0.0583644519 |
| GSE36640 | Up | 1.2297181076 |
| GSE54402 | Up | 0.2110256186 |
| GSE9593 | Down | -0.0770448850 |
| GSE43922 | Up | 0.3612414474 |
| GSE24585 | Up | 0.3579319258 |
| GSE37065 | Up | 0.1627297915 |
| GSE28863_A1 | Down | -0.0409469282 |
| GSE28863_A2 | Down | -0.2428176516 |
| GSE28863_A3 | Up | 0.1685967945 |
| GSE28863_A4 | Up | 0.0740168623 |
| GSE48662 | Down | -0.0307726853 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027077 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029386 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031656 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT043594 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26959556 | MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4 |
| 26959556 | SIRT4 expression significantly increased in human dermal fibroblasts undergoing replicative or stress-induced senescence triggered by UVB or gamma-irradiation |
| 26959556 | In-vivo, SIRT4 mRNA levels were upregulated in photoaged vs |
| 26959556 | Interestingly, in all models of cellular senescence and in photoaged skin, upregulation of SIRT4 expression was associated with decreased levels of miR-15b |
| 26959556 | The latter was causally linked to increased SIRT4 expression because miR-15b targets a functional binding site in the SIRT4 gene and transfection of oligonucleotides mimicking miR-15b function prevented SIRT4 upregulation in senescent cells |
| 26959556 | Importantly, increased SIRT4 negatively impacted on mitochondrial functions and contributed to the development of a senescent phenotype |
| 26959556 | Thus, miR-15b is a negative regulator of stress-induced SIRT4 expression thereby counteracting senescence associated mitochondrial dysfunction and regulating the SASP and possibly organ aging, such as photoaging of human skin |
| 26948035 | SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear |
| 23997094 | Similarly, sirtuin expression was relatively well-preserved in aorta from both genotypes, whereas expression of SIRT1, SIRT2, SIRT3, SIRT4, and SIRT6 were significantly reduced in the aortic valve |
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