HCSGD entry for SIRT5
1. General information
| Official gene symbol | SIRT5 |
|---|---|
| Entrez ID | 23408 |
| Gene full name | sirtuin 5 |
| Other gene symbols | SIR2L5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | TAS | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006342 | Chromatin silencing | TAS | biological_process |
| GO:0006471 | Protein ADP-ribosylation | TAS | biological_process |
| GO:0006476 | Protein deacetylation | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0036047 | Peptidyl-lysine demalonylation | IDA | biological_process |
| GO:0036048 | Protein desuccinylation | IDA | biological_process |
| GO:0036049 | Peptidyl-lysine desuccinylation | IDA | biological_process |
| GO:0036054 | Protein-malonyllysine demalonylase activity | IDA | molecular_function |
| GO:0036055 | Protein-succinyllysine desuccinylase activity | IDA | molecular_function |
| GO:0070403 | NAD+ binding | IDA | molecular_function |
| GO:2000378 | Negative regulation of reactive oxygen species metabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7874533832 | 0.6274379849 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0596082335 |
| GSE13712_SHEAR | Up | 0.1496521960 |
| GSE13712_STATIC | Up | 0.2580941066 |
| GSE19018 | Up | 0.0454006021 |
| GSE19899_A1 | Up | 0.0091117412 |
| GSE19899_A2 | Up | 0.1204810793 |
| PubMed_21979375_A1 | Down | -0.2292229649 |
| PubMed_21979375_A2 | Down | -0.0931068945 |
| GSE35957 | Up | 0.0267318108 |
| GSE36640 | Up | 0.2209043158 |
| GSE54402 | Down | -0.2613706675 |
| GSE9593 | Down | -0.0892015450 |
| GSE43922 | Down | -0.0223704872 |
| GSE24585 | Up | 0.0838751722 |
| GSE37065 | Down | -0.0277840177 |
| GSE28863_A1 | Down | -0.1763945292 |
| GSE28863_A2 | Down | -0.0778037126 |
| GSE28863_A3 | Down | -0.1770100500 |
| GSE28863_A4 | Up | 0.0286346090 |
| GSE48662 | Up | 0.3768356912 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-5-Diphosphoribose | DB02059 | EXPT00544 |
| Nicotinamide | DB02701 | EXPT02307 |
| 2'-O-Acetyl Adenosine-5-Diphosphoribose | DB03478 | EXPT02408 |
| Suramin | DB04786 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018521 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26948035 | SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear |
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