HCSGD entry for DICER1

1. General information

Official gene symbolDICER1
Entrez ID23405
Gene full namedicer 1, ribonuclease type III
Other gene symbolsDCR1 Dicer HERNA MNG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0004525Ribonuclease III activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006396RNA processingIEAbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010070Zygote asymmetric cell divisionIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010626Negative regulation of Schwann cell proliferationISSbiological_process
GO:0014040Positive regulation of Schwann cell differentiationISSbiological_process
GO:0016442RISC complexIDAcellular_component
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0021522Spinal cord motor neuron differentiationIEAbiological_process
GO:0021675Nerve developmentISSbiological_process
GO:0021889Olfactory bulb interneuron differentiationIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030422Production of siRNA involved in RNA interferenceIDA IEAbiological_process
GO:0030423Targeting of mRNA for destruction involved in RNA interferenceIMPbiological_process
GO:0030424AxonIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0031054Pre-miRNA processingIDA IEAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0031643Positive regulation of myelinationIEA ISSbiological_process
GO:0032290Peripheral nervous system myelin formationISSbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035196Production of miRNAs involved in gene silencing by miRNAISSbiological_process
GO:0035198MiRNA bindingIEAmolecular_function
GO:0035264Multicellular organism growthIEAbiological_process
GO:0045069Regulation of viral genome replicationIEAbiological_process
GO:0045664Regulation of neuron differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048536Spleen developmentIEAbiological_process
GO:0048713Regulation of oligodendrocyte differentiationIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:0048812Neuron projection morphogenesisISSbiological_process
GO:0051225Spindle assemblyIEAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0055013Cardiac muscle cell developmentIEAbiological_process
GO:0060119Inner ear receptor cell developmentIEAbiological_process
GO:0060576Intestinal epithelial cell developmentIEAbiological_process
GO:0070173Regulation of enamel mineralizationIEAbiological_process
GO:0071335Hair follicle cell proliferationIEAbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDAbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDAbiological_process
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticIDAbiological_process
GO:2000630Positive regulation of miRNA metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17711922800.29793822800.82644126931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2623724141
GSE13712_SHEARUp0.0857919439
GSE13712_STATICUp0.0600128967
GSE19018Up0.0577237151
GSE19899_A1Down-0.3179074978
GSE19899_A2Down-0.3356119080
PubMed_21979375_A1Down-0.3726089501
PubMed_21979375_A2Down-0.1783663747
GSE35957Up0.3001808257
GSE36640Up0.1833184278
GSE54402Down-0.4269438010
GSE9593Down-0.1147486600
GSE43922Down-0.0491263318
GSE24585Down-0.1747902179
GSE37065Down-0.0399194456
GSE28863_A1Up1.3512299795
GSE28863_A2Up1.2248050017
GSE28863_A3Up0.2016108441
GSE28863_A4Up0.1164046535
GSE48662Up0.0753032590

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT006379Luciferase reporter assayFunctional MTI21761362
hsa-miR-222-3pMIMAT0000279MIRT006377Luciferase reporter assayFunctional MTI21761362
hsa-miR-221-3pMIMAT0000278MIRT006376Luciferase reporter assayFunctional MTI21761362
hsa-let-7a-5pMIMAT0000062MIRT004346Luciferase reporter assay//Western blot//Northern blotFunctional MTI18700235
hsa-let-7a-5pMIMAT0000062MIRT004346CLASHFunctional MTI (Weak)23622248
hsa-let-7d-5pMIMAT0000065MIRT004347Luciferase reporter assay//Western blot//Northern blotFunctional MTI18700235
hsa-let-7c-5pMIMAT0000064MIRT004348Western blot//Northern blotNon-Functional MTI18700235
hsa-let-7b-5pMIMAT0000063MIRT005322ImmunoblotFunctional MTI (Weak)18812516
hsa-miR-103a-3pMIMAT0000101MIRT005347Luciferase reporter assay//qRT-PCRFunctional MTI20603000
hsa-miR-103a-3pMIMAT0000101MIRT005347SequencingFunctional MTI (Weak)20371350
hsa-miR-107MIMAT0000104MIRT005348Luciferase reporter assay//qRT-PCRFunctional MTI20603000
hsa-miR-519a-3pMIMAT0002869MIRT005571Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21274007
hsa-miR-374a-5pMIMAT0000727MIRT005572Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21274007
hsa-miR-154-5pMIMAT0000452MIRT005679Luciferase reporter assayNon-Functional MTI20603000
hsa-miR-130a-3pMIMAT0000425MIRT006258Luciferase reporter assayFunctional MTI22350415
hsa-miR-18a-5pMIMAT0000072MIRT007178Immunohistochemistry//In situ hybridization//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI23097559
hsa-miR-18a-5pMIMAT0000072MIRT007178SequencingFunctional MTI (Weak)20371350
hsa-miR-130b-3pMIMAT0000691MIRT007384Luciferase reporter assayFunctional MTI23392577
hsa-miR-425-5pMIMAT0003393MIRT016677SequencingFunctional MTI (Weak)20371350
hsa-miR-29c-3pMIMAT0000681MIRT020398SequencingFunctional MTI (Weak)20371350
hsa-miR-215-5pMIMAT0000272MIRT024517MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026884MicroarrayFunctional MTI (Weak)19074876
hsa-miR-98-5pMIMAT0000096MIRT027858MicroarrayFunctional MTI (Weak)19088304
hsa-miR-296-3pMIMAT0004679MIRT038408CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051245CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7a-5pMIMAT00000621hsa-let-7a{Western blot}{overexpression by miRNA precursor transfection}18700235
hsa-let-7d-5pMIMAT00000651hsa-let-7d{Western blot}{overexpression by miRNA precursor transfection}18700235
hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b{Western blot}{overexpression}20194440
hsa-miR-107MIMAT00001041hsa-miR-107{Western blot}{downregulation}21029372
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26990999Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence
26990999Here, we show that metformin treatment increases the levels of the microRNA-processing protein DICER1 in mice and in humans with diabetes mellitus
26990999Our results indicate that metformin upregulates DICER1 through a post-transcriptional mechanism involving the RNA-binding protein AUF1
26990999Treatment with metformin altered the subcellular localization of AUF1, disrupting its interaction with DICER1 mRNA and rendering DICER1 mRNA stable, allowing DICER1 to accumulate
26990999Consistent with the role of DICER1 in the biogenesis of microRNAs, we found differential patterns of microRNA expression in mice treated with metformin or caloric restriction, two proven life-extending interventions
26990999These data lead us to hypothesize that changes in DICER1 levels may be important for organismal aging and to propose that interventions that upregulate DICER1 expression (e
25361944Gene knockdown of Dicer1, which was down-regulated in mesenchymal stromal cells from patients, induced senescence
25361944The differentiation and stem cell-supporting capacities were significantly inhibited by Dicer1 knockdown
25361944Overexpression of Dicer1 in mesenchymal stromal cells from patients reversed cellular senescence and enhanced stem cell properties
25361944Collectively, the results of our study show that mesenchymal stromal cells from patients with myelodysplastic syndrome are prone to senescence and that Dicer1 down-regulation promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells
25361944Dicer1 down-regulation seems to contribute to the insufficient hematopoietic support capacities of mesenchymal stromal cells from patients with myelodysplastic syndrome
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