HCSGD entry for EXOSC2
1. General information
| Official gene symbol | EXOSC2 |
|---|---|
| Entrez ID | 23404 |
| Gene full name | exosome component 2 |
| Other gene symbols | RRP4 Rrp4p hRrp4p p7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000175 | 3'-5'-exoribonuclease activity | TAS | molecular_function |
| GO:0000178 | Exosome (RNase complex) | IDA IEA | cellular_component |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004527 | Exonuclease activity | IEA | molecular_function |
| GO:0004532 | Exoribonuclease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006364 | RRNA processing | IEA | biological_process |
| GO:0008312 | 7S RNA binding | TAS | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030307 | Positive regulation of cell growth | IMP | biological_process |
| GO:0043928 | Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | TAS | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9132089320 | 0.0554047111 | 0.9999902473 | 0.4434101551 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0747007358 |
| GSE13712_SHEAR | Up | 0.0977299159 |
| GSE13712_STATIC | Up | 0.1122802159 |
| GSE19018 | Down | -0.1001347480 |
| GSE19899_A1 | Down | -0.0925204672 |
| GSE19899_A2 | Up | 0.0089169020 |
| PubMed_21979375_A1 | Up | 0.6322253208 |
| PubMed_21979375_A2 | Down | -0.7608779822 |
| GSE35957 | Down | -0.4099552624 |
| GSE36640 | Down | -1.2310268930 |
| GSE54402 | Up | 0.2446016400 |
| GSE9593 | Down | -0.5088365151 |
| GSE43922 | Down | -0.0324339348 |
| GSE24585 | Down | -0.2755923851 |
| GSE37065 | Down | -0.2270363365 |
| GSE28863_A1 | Up | 0.0565165135 |
| GSE28863_A2 | Down | -0.0569139481 |
| GSE28863_A3 | Down | -0.3644887158 |
| GSE28863_A4 | Up | 0.1978583049 |
| GSE48662 | Down | -0.5034694159 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020557 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025693 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-484 | MIMAT0002174 | MIRT041732 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-3p | MIMAT0000088 | MIRT049922 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
