HCSGD entry for NCSTN
1. General information
| Official gene symbol | NCSTN |
|---|---|
| Entrez ID | 23385 |
| Gene full name | nicastrin |
| Other gene symbols | APH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002262 | Myeloid cell homeostasis | IEA | biological_process |
| GO:0004175 | Endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA IEA ISS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | IEA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA ISS | cellular_component |
| GO:0006508 | Proteolysis | NAS | biological_process |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA ISS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007220 | Notch receptor processing | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0016485 | Protein processing | IDA IEA ISS | biological_process |
| GO:0031293 | Membrane protein intracellular domain proteolysis | TAS | biological_process |
| GO:0042098 | T cell proliferation | IEA | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0042987 | Amyloid precursor protein catabolic process | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | IDA ISS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050435 | Beta-amyloid metabolic process | IEA | biological_process |
| GO:0050673 | Epithelial cell proliferation | IEA | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0685639717 | 0.9297207743 | 0.5620281221 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1040639138 |
| GSE13712_SHEAR | Up | 0.1059009710 |
| GSE13712_STATIC | Up | 0.0814651831 |
| GSE19018 | Up | 0.4252081679 |
| GSE19899_A1 | Down | -0.0801445423 |
| GSE19899_A2 | Up | 0.4696081084 |
| PubMed_21979375_A1 | Up | 0.4266713727 |
| PubMed_21979375_A2 | Up | 0.1858247163 |
| GSE35957 | Down | -0.1002082825 |
| GSE36640 | Up | 0.4444633719 |
| GSE54402 | Down | -0.0075250725 |
| GSE9593 | Up | 0.2228980244 |
| GSE43922 | Up | 0.0375948114 |
| GSE24585 | Up | 0.4560362446 |
| GSE37065 | Up | 0.2164977749 |
| GSE28863_A1 | Up | 0.2995406010 |
| GSE28863_A2 | Up | 0.2447805148 |
| GSE28863_A3 | Down | -0.5396155689 |
| GSE28863_A4 | Down | -0.1673715508 |
| GSE48662 | Up | 0.3433379996 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030869 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038892 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039146 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042811 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047572 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
