HCSGD entry for ARHGEF18

1. General information

Official gene symbolARHGEF18
Entrez ID23370
Gene full nameRho/Rac guanine nucleotide exchange factor (GEF) 18
Other gene symbolsP114-RhoGEF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionIDA TASbiological_process
GO:0008360Regulation of cell shapeIDAbiological_process
GO:0030036Actin cytoskeleton organizationIDAbiological_process
GO:0030054Cell junctionTAScellular_component
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0045177Apical part of cellIDAcellular_component
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18813972490.70262167090.84519981231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3031953443
GSE13712_SHEARUp0.4715419738
GSE13712_STATICUp0.3514547622
GSE19018Down-0.2324343207
GSE19899_A1Down-0.5941286922
GSE19899_A2Up0.3905611051
PubMed_21979375_A1Down-0.2411817716
PubMed_21979375_A2Up0.6975636547
GSE35957Down-0.3588728122
GSE36640Down-0.0911324274
GSE54402Down-0.1029865880
GSE9593Up0.1645995160
GSE43922Up0.0479092967
GSE24585Up0.1171817053
GSE37065Down-0.1401672741
GSE28863_A1Up0.0208478713
GSE28863_A2Up0.2273048764
GSE28863_A3Up0.0941211998
GSE28863_A4Down-0.0201745394
GSE48662Up0.3209938885

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002801MicroarrayFunctional MTI (Weak)15685193
hsa-miR-1MIMAT0000416MIRT002801MicroarrayFunctional MTI (Weak)18668037
hsa-miR-24-3pMIMAT0000080MIRT030443MicroarrayFunctional MTI (Weak)19748357
hsa-miR-221-3pMIMAT0000278MIRT046963CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.