HCSGD entry for PPP1R13B
1. General information
| Official gene symbol | PPP1R13B |
|---|---|
| Entrez ID | 23368 |
| Gene full name | protein phosphatase 1, regulatory subunit 13B |
| Other gene symbols | ASPP1 p53BP2-like p85 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0045786 | Negative regulation of cell cycle | IEA TAS | biological_process |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6695500513 | 0.2773586262 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0797809498 |
| GSE13712_SHEAR | Up | 0.0654759456 |
| GSE13712_STATIC | Down | -0.0998036774 |
| GSE19018 | Down | -0.3064500387 |
| GSE19899_A1 | Down | -0.0255172491 |
| GSE19899_A2 | Down | -0.0367716205 |
| PubMed_21979375_A1 | Down | -0.9410812682 |
| PubMed_21979375_A2 | Down | -0.0581806787 |
| GSE35957 | Down | -0.4314555593 |
| GSE36640 | Down | -0.2651727337 |
| GSE54402 | Up | 0.0536389468 |
| GSE9593 | Up | 0.0790541517 |
| GSE43922 | Up | 0.0159104054 |
| GSE24585 | Up | 0.6759940428 |
| GSE37065 | Down | -0.1490399235 |
| GSE28863_A1 | Up | 0.0355707023 |
| GSE28863_A2 | Up | 0.0110886309 |
| GSE28863_A3 | Up | 0.1781629675 |
| GSE28863_A4 | Up | 0.0500390864 |
| GSE48662 | Up | 0.0112344867 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | MIRT006485 | Luciferase reporter assay//Western blot | Functional MTI | 19079265 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT006486 | Luciferase reporter assay//Western blot | Functional MTI | 19079265 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT006487 | Luciferase reporter assay//Western blot | Functional MTI | 19079265 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038764 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039041 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039385 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT040984 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT045828 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047417 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23392125 | ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells |
| 23392125 | In cancer cells, ASPP1 and ASPP2 cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 |
| 23392125 | Thus, loss of ASPP1 and ASPP2 in human cancer cells may contribute to the full transforming property of RAS oncogene |
| 22068052 | An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence |
| 22068052 | In addition to acting as a transcriptional cofactor for p53, ASPP1 has been shown to function in the cytoplasm to regulate the nuclear localization and activity of YAP/TAZ |
| 22068052 | We show here that the ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability of p53 to induce p21, cell-cycle arrest and senescence |
| 22068052 | ASPP1 expression peaks in S-phase, and down-regulation of ASPP1 leads to a reduction in DNA synthesis and enhanced senescence in response to drugs that impede DNA replication |
| 22068052 | These activities of cytoplasmic ASPP1 in opposing p53-mediated p21 expression are in contrast to the role of nuclear ASPP1 in cooperating with p53 to induce the expression of apoptotic target genes, and may help to dampen p53 activity in normal cells |
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