HCSGD entry for ARHGEF12
1. General information
| Official gene symbol | ARHGEF12 |
|---|---|
| Entrez ID | 23365 |
| Gene full name | Rho guanine nucleotide exchange factor (GEF) 12 |
| Other gene symbols | LARG PRO2792 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IDA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0038032 | Termination of G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8397840432 | 0.4590095969 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0196568931 |
| GSE13712_SHEAR | Down | -0.0587814987 |
| GSE13712_STATIC | Down | -0.0578808801 |
| GSE19018 | Up | 0.0770412927 |
| GSE19899_A1 | Up | 0.0084802466 |
| GSE19899_A2 | Up | 0.0445887136 |
| PubMed_21979375_A1 | Down | -0.4297566528 |
| PubMed_21979375_A2 | Up | 0.0294262818 |
| GSE35957 | Up | 0.0849493104 |
| GSE36640 | Down | -0.0316129404 |
| GSE54402 | Down | -0.0615200751 |
| GSE9593 | Up | 0.0118065993 |
| GSE43922 | Down | -0.0633024283 |
| GSE24585 | Down | -0.0435140360 |
| GSE37065 | Up | 0.0121707791 |
| GSE28863_A1 | Up | 0.4471460142 |
| GSE28863_A2 | Up | 0.3594684778 |
| GSE28863_A3 | Down | -0.5852729406 |
| GSE28863_A4 | Up | 0.0277897915 |
| GSE48662 | Down | -0.2465851095 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030993 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1225-3p | MIMAT0005573 | MIRT036542 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047997 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
