HCSGD entry for SUN1
1. General information
| Official gene symbol | SUN1 |
|---|---|
| Entrez ID | 23353 |
| Gene full name | Sad1 and UNC84 domain containing 1 |
| Other gene symbols | UNC84A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002080 | Acrosomal membrane | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005521 | Lamin binding | IEA | molecular_function |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005639 | Integral component of nuclear inner membrane | IEA | cellular_component |
| GO:0006998 | Nuclear envelope organization | IGI | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0034993 | SUN-KASH complex | IDA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0090286 | Cytoskeletal anchoring at nuclear membrane | IDA | biological_process |
| GO:0090292 | Nuclear matrix anchoring at nuclear membrane | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9018601687 | 0.0660584628 | 0.9999902473 | 0.4851352679 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2547784868 |
| GSE13712_SHEAR | Down | -0.0613999484 |
| GSE13712_STATIC | Down | -0.1240307482 |
| GSE19018 | Up | 0.0918507246 |
| GSE19899_A1 | Down | -0.2770533122 |
| GSE19899_A2 | Down | -0.1818836130 |
| PubMed_21979375_A1 | Down | -0.8591794968 |
| PubMed_21979375_A2 | Down | -0.5500584401 |
| GSE35957 | Down | -0.1942604852 |
| GSE36640 | Down | -0.3625502804 |
| GSE54402 | Down | -0.3355464317 |
| GSE9593 | Down | -0.1541643849 |
| GSE43922 | Down | -0.4550383313 |
| GSE24585 | Up | 0.2620319772 |
| GSE37065 | Down | -0.1217359601 |
| GSE28863_A1 | Up | 0.4465093772 |
| GSE28863_A2 | Up | 0.8864476123 |
| GSE28863_A3 | Down | -0.0107339240 |
| GSE28863_A4 | Down | -0.1931672908 |
| GSE48662 | Up | 0.0877384858 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029149 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040822 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041459 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22895095 | Reversal of laminopathies: the curious case of SUN1 |
| 22895095 | This conclusion arose from the unexpected observation that the deletion of Sun1, instead of accelerating aging, actually ameliorated the progeric and dystrophic phenotypes in Lmna-deficient mice |
| 22895095 | Here we offer additional comments on the contributions of SUN1 and the process of normal protein turnover to cellular aging |
| 22541428 | Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies |
| 22541428 | Unexpectedly, Lmna(-/-) or LmnaDelta9 mice that are also deficient for the inner nuclear membrane protein Sun1 show markedly reduced tissue pathologies and enhanced longevity |
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