HCSGD entry for SYNE1

1. General information

Official gene symbolSYNE1
Entrez ID23345
Gene full namespectrin repeat containing, nuclear envelope 1
Other gene symbols8B ARCA1 C6orf98 CPG2 EDMD4 MYNE1 Nesp1 SCAR8 dJ45H2.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005521Lamin bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005635Nuclear envelopeIDAcellular_component
GO:0005640Nuclear outer membraneIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006997Nucleus organizationNASbiological_process
GO:0007030Golgi organizationIDAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0030017SarcomereIDAcellular_component
GO:0031965Nuclear membraneIDAcellular_component
GO:0034993SUN-KASH complexIDAcellular_component
GO:0040023Establishment of nucleus localizationIEAbiological_process
GO:0042692Muscle cell differentiationIDAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0045211Postsynaptic membraneIDAcellular_component
GO:0051015Actin filament bindingISSmolecular_function
GO:0090286Cytoskeletal anchoring at nuclear membraneIDAbiological_process
GO:0090292Nuclear matrix anchoring at nuclear membraneIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02533694770.44679156950.37368504201.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4494679799
GSE13712_SHEARUp1.0548882101
GSE13712_STATICUp0.2787136152
GSE19018Up0.2837607648
GSE19899_A1Down-0.2593304594
GSE19899_A2Down-0.6165566353
PubMed_21979375_A1Down-0.2135585543
PubMed_21979375_A2Down-0.4902389372
GSE35957Up0.5075952789
GSE36640Up0.7024969707
GSE54402Down-0.4761949369
GSE9593Up0.3364733549
GSE43922Up0.0161283495
GSE24585Up0.1539401153
GSE37065Up0.2344015960
GSE28863_A1Up1.0701738812
GSE28863_A2Up0.5107337142
GSE28863_A3Up0.7159574664
GSE28863_A4Down-0.2252000716
GSE48662Up0.1503056539

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001329pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-148b-3pMIMAT0000759MIRT019351MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021329MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022525Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029291MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT032256ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.