HCSGD entry for NEDD4L

1. General information

Official gene symbolNEDD4L
Entrez ID23327
Gene full nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Other gene symbolsNEDD4-2 NEDD4.2 RSP5 hNEDD4-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0003085Negative regulation of systemic arterial blood pressureIEAbiological_process
GO:0003254Regulation of membrane depolarizationIDAbiological_process
GO:0004842Ubiquitin-protein ligase activityIBA IEA NAS TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularICcellular_component
GO:0005634NucleusIBAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006513Protein monoubiquitinationIEAbiological_process
GO:0006814Sodium ion transportNASbiological_process
GO:0006883Cellular sodium ion homeostasisNASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007588ExcretionNASbiological_process
GO:0009651Response to salt stressIEAbiological_process
GO:0010038Response to metal ionIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010765Positive regulation of sodium ion transportIEAbiological_process
GO:0010766Negative regulation of sodium ion transportIEAbiological_process
GO:0015459Potassium channel regulator activityIDAmolecular_function
GO:0016032Viral processTASbiological_process
GO:0016567Protein ubiquitinationIDA NASbiological_process
GO:0017080Sodium channel regulator activityIDAmolecular_function
GO:0019870Potassium channel inhibitor activityIDA IEAmolecular_function
GO:0019871Sodium channel inhibitor activityIDA IEAmolecular_function
GO:0030104Water homeostasisNASbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0042176Regulation of protein catabolic processNASbiological_process
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIBA IDAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0043162Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayIEAbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0045732Positive regulation of protein catabolic processIEAbiological_process
GO:0045807Positive regulation of endocytosisNASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060306Regulation of membrane repolarizationIDAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIEA ISSbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityIDAbiological_process
GO:1901017Negative regulation of potassium ion transmembrane transporter activityIDA IEAbiological_process
GO:1901380Negative regulation of potassium ion transmembrane transportIDAbiological_process
GO:1902306Negative regulation of sodium ion transmembrane transportIDAbiological_process
GO:2000009Negative regulation of protein localization to cell surfaceIDAbiological_process
GO:2000650Negative regulation of sodium ion transmembrane transporter activityIDAbiological_process
GO:2000810Regulation of tight junction assemblyIEAbiological_process
GO:2001259Positive regulation of cation channel activityIEAbiological_process
GO:2001288Positive regulation of caveolin-mediated endocytosisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01814906730.87651134840.32990441991.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2761450490
GSE13712_SHEARUp0.6237377381
GSE13712_STATICUp0.6143159920
GSE19018Up0.3319735695
GSE19899_A1Down-0.0572751510
GSE19899_A2Up0.4122843159
PubMed_21979375_A1Up0.1848881006
PubMed_21979375_A2Up0.3957762878
GSE35957Down-0.1776247766
GSE36640Down-0.3874553821
GSE54402Down-0.4230183838
GSE9593Up0.1634146762
GSE43922Up0.4695417624
GSE24585Down-0.2737844395
GSE37065Up0.3383861949
GSE28863_A1Up0.3462508948
GSE28863_A2Up1.3572164127
GSE28863_A3Up0.4882661056
GSE28863_A4Up0.0697448960
GSE48662Down-0.1179036250

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT030590MicroarrayFunctional MTI (Weak)19748357
hsa-miR-1296-5pMIMAT0005794MIRT036071CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038151CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.