HCSGD entry for USP22
1. General information
| Official gene symbol | USP22 |
|---|---|
| Entrez ID | 23326 |
| Gene full name | ubiquitin specific peptidase 22 |
| Other gene symbols | USP3L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000124 | SAGA complex | IDA | cellular_component |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009790 | Embryo development | NAS | biological_process |
| GO:0010485 | H4 histone acetyltransferase activity | IDA | molecular_function |
| GO:0016573 | Histone acetylation | IDA | biological_process |
| GO:0016574 | Histone ubiquitination | IDA | biological_process |
| GO:0016578 | Histone deubiquitination | IDA | biological_process |
| GO:0016579 | Protein deubiquitination | IDA IEA | biological_process |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IMP | molecular_function |
| GO:0043967 | Histone H4 acetylation | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0070461 | SAGA-type complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7788018122 | 0.5937543748 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0637385505 |
| GSE13712_SHEAR | Down | -0.0396291903 |
| GSE13712_STATIC | Up | 0.1059065537 |
| GSE19018 | Down | -0.1765586559 |
| GSE19899_A1 | Down | -0.0376313953 |
| GSE19899_A2 | Down | -0.0063501109 |
| PubMed_21979375_A1 | Up | 0.1497594558 |
| PubMed_21979375_A2 | Down | -0.1584095824 |
| GSE35957 | Up | 0.0060543781 |
| GSE36640 | Down | -0.0195037754 |
| GSE54402 | Up | 0.0786053326 |
| GSE9593 | Down | -0.0535959429 |
| GSE43922 | Down | -0.0322165672 |
| GSE24585 | Up | 0.0510602762 |
| GSE37065 | Down | -0.1020689520 |
| GSE28863_A1 | Up | 0.6393262360 |
| GSE28863_A2 | Down | -0.0370999374 |
| GSE28863_A3 | Down | -0.3134868536 |
| GSE28863_A4 | Down | -0.0572099836 |
| GSE48662 | Up | 0.1304785542 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-5p | MIMAT0004673 | MIRT038544 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-2-3p | MIMAT0004603 | MIRT038630 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-346 | MIMAT0000773 | MIRT042724 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044046 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044092 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT044385 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044650 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052073 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
