HCSGD entry for SIN3B
1. General information
| Official gene symbol | SIN3B |
|---|---|
| Entrez ID | 23309 |
| Gene full name | SIN3 transcription regulator homolog B (yeast) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000805 | X chromosome | IEA | cellular_component |
| GO:0000806 | Y chromosome | IEA | cellular_component |
| GO:0001741 | XY body | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0030849 | Autosome | IEA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0048738 | Cardiac muscle tissue development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1088491813 | 0.9500016337 | 0.6834853327 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0454418531 |
| GSE13712_SHEAR | Up | 0.1624942218 |
| GSE13712_STATIC | Up | 0.1042289499 |
| GSE19018 | Down | -0.0435706399 |
| GSE19899_A1 | Down | -0.0700256466 |
| GSE19899_A2 | Up | 0.7204016011 |
| PubMed_21979375_A1 | Up | 0.1353095368 |
| PubMed_21979375_A2 | Up | 1.0824914673 |
| GSE35957 | Down | -0.0396877198 |
| GSE36640 | Up | 0.6024930728 |
| GSE54402 | Up | 0.0962623894 |
| GSE9593 | Up | 0.2395605584 |
| GSE43922 | Up | 0.0966844128 |
| GSE24585 | Down | -0.1678105058 |
| GSE37065 | Down | -0.1018932599 |
| GSE28863_A1 | Up | 0.1566892206 |
| GSE28863_A2 | Up | 0.1908457684 |
| GSE28863_A3 | Down | -0.0239743555 |
| GSE28863_A4 | Down | -0.0253528570 |
| GSE48662 | Up | 0.5432367873 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019064 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045249 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049321 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27308374 | SIN3B, the SASP, and pancreatic cancer |
| 25263442 | Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation |
| 25263442 | The expression of the chromatin-associated Sin3B protein is stimulated by oncogenic stress, and is required for oncogene-induced senescence |
| 25263442 | Here we demonstrate that oncogenic stress leads to the dissociation of Bmi-1 from the Sin3B locus, resulting in increased Sin3B expression and subsequent entry into cellular senescence |
| 25263442 | Furthermore, Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion |
| 25263442 | Altogether, these results identify Sin3B as a novel direct target of Bmi-1, and establish Bmi-1-driven repression of Sin3B as an essential regulator of cellular senescence |
| 19654306 | Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress |
| 19654306 | We show that fibroblasts genetically inactivated for the chromatin-associated Sin3B protein are refractory to replicative and oncogene-induced senescence |
| 19654306 | Conversely, overexpression of Sin3B triggers senescence and the formation of senescence-associated heterochromatic foci |
| 19654306 | Although Sin3B is strongly up-regulated upon oncogenic stress, decrease in expression of Sin3B is associated with tumor progression in vivo, suggesting that expression of Sin3B may represent a barrier against transformation |
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