HCSGD entry for ICOSLG

1. General information

Official gene symbolICOSLG
Entrez ID23308
Gene full nameinducible T-cell co-stimulator ligand
Other gene symbolsB7-H2 B7H2 B7RP-1 B7RP1 CD275 GL50 ICOS-L ICOSL LICOS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingTASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006952Defense responseNASbiological_process
GO:0006972Hyperosmotic responseNASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0042104Positive regulation of activated T cell proliferationTASbiological_process
GO:0042110T cell activationNASbiological_process
GO:0042113B cell activationIEAbiological_process
GO:0045404Positive regulation of interleukin-4 biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27084914710.95607682840.96807272601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0202705461
GSE13712_SHEARDown-0.0837903658
GSE13712_STATICDown-0.1890957671
GSE19018Down-0.0273575050
GSE19899_A1Up0.0013978080
GSE19899_A2Up0.2005330752
PubMed_21979375_A1Up0.1621325436
PubMed_21979375_A2Down-0.0318658864
GSE35957Up0.1067590588
GSE36640Up0.0539983638
GSE54402Up0.0678974742
GSE9593Up0.0373695027
GSE43922Up0.1056885262
GSE24585Up0.0694039364
GSE37065Up0.5156084290
GSE28863_A1Down-0.0124305439
GSE28863_A2Up0.1829901889
GSE28863_A3Up0.4061485620
GSE28863_A4Up0.2133116932
GSE48662Down-0.0142699574

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-766-3pMIMAT0003888MIRT039046CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.