HCSGD entry for ATMIN
1. General information
| Official gene symbol | ATMIN |
|---|---|
| Entrez ID | 23300 |
| Gene full name | ATM interactor |
| Other gene symbols | ASCIZ ZNF822 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IEA | molecular_function |
| GO:0045502 | Dynein binding | IPI | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2133763573 | 0.8957967706 | 0.8900600792 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6000483674 |
| GSE13712_SHEAR | Up | 0.1349370166 |
| GSE13712_STATIC | Up | 0.0521228807 |
| GSE19018 | Down | -0.4126613819 |
| GSE19899_A1 | Up | 0.1096877486 |
| GSE19899_A2 | Up | 0.3513043783 |
| PubMed_21979375_A1 | Up | 0.1656920344 |
| PubMed_21979375_A2 | Up | 0.3536258602 |
| GSE35957 | Up | 0.0810758178 |
| GSE36640 | Up | 0.1581250864 |
| GSE54402 | Up | 0.3501685800 |
| GSE9593 | Up | 0.1080124506 |
| GSE43922 | Down | -0.0333511059 |
| GSE24585 | Down | -0.0418597145 |
| GSE37065 | Up | 0.0617432548 |
| GSE28863_A1 | Down | -0.0199336501 |
| GSE28863_A2 | Up | 0.1631430830 |
| GSE28863_A3 | Down | -0.1463042477 |
| GSE28863_A4 | Down | -0.0026449809 |
| GSE48662 | Down | -0.0681858454 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020249 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031014 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031215 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037692 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-3p | MIMAT0001343 | MIRT042422 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20889973 | The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain |
| 20889973 | Here we identify ATM interactor (ATMIN) as an essential component of the ATM signaling pathway in response to oxidative stress and aging |
| 20889973 | Embryos lacking ATMIN (atmin(Delta/Delta)) died in utero and showed increased numbers of cells positive for phosphorylated histone H2aX, indicative of increased DNA damage |
| 20889973 | Conditional deletion of ATMIN in the murine nervous system (atmin(DeltaN)) resulted in reduced numbers of dopaminergic neurons, as does ATM deficiency |
| 20889973 | ATM activity was observed in old, but not in young, control mice, but aging-induced ATM signaling was impaired by ATMIN deficiency |
| 20889973 | These results suggest that ATMIN mediates ATM activation by oxidative stress, and thereby ATMIN protects the aging brain by preventing accumulation of DNA damage |
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