HCSGD entry for MGRN1
1. General information
| Official gene symbol | MGRN1 |
|---|---|
| Entrez ID | 23295 |
| Gene full name | mahogunin ring finger 1, E3 ubiquitin protein ligase |
| Other gene symbols | RNF156 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA | cellular_component |
| GO:0006513 | Protein monoubiquitination | IMP | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008333 | Endosome to lysosome transport | IMP | biological_process |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0043951 | Negative regulation of cAMP-mediated signaling | IDA | biological_process |
| GO:0045744 | Negative regulation of G-protein coupled receptor protein signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0347494966 | 0.9507601497 | 0.4261199164 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4106242883 |
| GSE13712_SHEAR | Up | 0.2579841245 |
| GSE13712_STATIC | Up | 0.3016590766 |
| GSE19018 | Down | -0.2292512172 |
| GSE19899_A1 | Up | 0.0012700570 |
| GSE19899_A2 | Up | 0.6355122021 |
| PubMed_21979375_A1 | Up | 1.6195461853 |
| PubMed_21979375_A2 | Up | 2.1745575618 |
| GSE35957 | Down | -0.3555397960 |
| GSE36640 | Up | 0.3388151366 |
| GSE54402 | Up | 0.2608192252 |
| GSE9593 | Up | 0.0666334834 |
| GSE43922 | Up | 0.0073235031 |
| GSE24585 | Down | -0.1373250223 |
| GSE37065 | Down | -0.0787193651 |
| GSE28863_A1 | Up | 0.1910718194 |
| GSE28863_A2 | Up | 0.2853569938 |
| GSE28863_A3 | Up | 0.1579068370 |
| GSE28863_A4 | Down | -0.0635761064 |
| GSE48662 | Up | 0.0678230682 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037554 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037832 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181d-5p | MIMAT0002821 | MIRT041179 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
