HCSGD entry for SCFD1
1. General information
| Official gene symbol | SCFD1 |
|---|---|
| Entrez ID | 23256 |
| Gene full name | sec1 family domain containing 1 |
| Other gene symbols | C14orf163 RA410 SLY1 SLY1P STXBP1L2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005798 | Golgi-associated vesicle | IEA ISS | cellular_component |
| GO:0005801 | Cis-Golgi network | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA ISS | cellular_component |
| GO:0006890 | Retrograde vesicle-mediated transport, Golgi to ER | IEA ISS | biological_process |
| GO:0006892 | Post-Golgi vesicle-mediated transport | IEA ISS | biological_process |
| GO:0006904 | Vesicle docking involved in exocytosis | IEA | biological_process |
| GO:0009636 | Response to toxic substance | IEP | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0017119 | Golgi transport complex | IEA ISS | cellular_component |
| GO:0019905 | Syntaxin binding | IEA ISS | molecular_function |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0047485 | Protein N-terminus binding | IEA | molecular_function |
| GO:0060628 | Regulation of ER to Golgi vesicle-mediated transport | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2497806656 | 0.8247218571 | 0.9387562250 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1259739620 |
| GSE13712_SHEAR | Up | 0.1981592751 |
| GSE13712_STATIC | Up | 0.0236930655 |
| GSE19018 | Down | -0.0131743511 |
| GSE19899_A1 | Up | 0.1453170635 |
| GSE19899_A2 | Up | 0.3475187926 |
| PubMed_21979375_A1 | Up | 0.3722780280 |
| PubMed_21979375_A2 | Up | 0.1264130401 |
| GSE35957 | Down | -0.0189627682 |
| GSE36640 | Up | 0.2024580642 |
| GSE54402 | Up | 0.0459422396 |
| GSE9593 | Down | -0.1109387034 |
| GSE43922 | Up | 0.1886085011 |
| GSE24585 | Up | 0.3589062824 |
| GSE37065 | Down | -0.0831046893 |
| GSE28863_A1 | Up | 0.3075565676 |
| GSE28863_A2 | Down | -0.0171727552 |
| GSE28863_A3 | Down | -0.5449035751 |
| GSE28863_A4 | Up | 0.0985304794 |
| GSE48662 | Down | -0.2667582361 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT044947 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 28123874 | Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance |
| 28123874 | We identified a correlation between NK levels of the X-chromosome-located adaptor protein SLy1 and immunologic susceptibility to cancer |
| 28123874 | Unlike the case for T or B lymphocytes, where SLy1 shuttles between the cytoplasm and nucleus to facilitate signal transduction, in NK cells SLy1 functions as a ribosomal protein and is located solely in the cytoplasm |
| 28123874 | NK defects are reversible under inflammatory conditions and viral clearance is not impacted by SLy1 deficiency |
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