HCSGD entry for FLT4

1. General information

Official gene symbolFLT4
Entrez ID2324
Gene full namefms-related tyrosine kinase 4
Other gene symbolsFLT41 LMPH1A PCL VEGFR3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIMPbiological_process
GO:0001944Vasculature developmentISSbiological_process
GO:0001945Lymph vessel developmentISSbiological_process
GO:0001946LymphangiogenesisIEA IMP ISSbiological_process
GO:0002040Sprouting angiogenesisIEA ISSbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIMPmolecular_function
GO:0005021Vascular endothelial growth factor-activated receptor activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0008284Positive regulation of cell proliferationIEA IGI IMPbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionIMPbiological_process
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019838Growth factor bindingIPImolecular_function
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0035924Cellular response to vascular endothelial growth factor stimulusIDA IMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043410Positive regulation of MAPK cascadeIMPbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIDA IEA IGI IMP TASbiological_process
GO:0048514Blood vessel morphogenesisISSbiological_process
GO:0060312Regulation of blood vessel remodelingIEA ISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0090037Positive regulation of protein kinase C signalingIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81211340370.35907606090.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0253530763
GSE13712_SHEARDown-0.8097520633
GSE13712_STATICDown-1.5938119558
GSE19018Up0.1207247653
GSE19899_A1Down-0.0507495545
GSE19899_A2Up0.0264205040
PubMed_21979375_A1Up0.0723971818
PubMed_21979375_A2Down-0.0532053856
GSE35957Up0.0232253649
GSE36640Down-0.0137429978
GSE54402Down-0.0572500979
GSE9593Up0.0359782960
GSE43922Up0.0304570592
GSE24585Up0.0248311725
GSE37065Down-0.0418003587
GSE28863_A1Down-0.1091936608
GSE28863_A2Up0.1794877072
GSE28863_A3Up0.2295139977
GSE28863_A4Up0.1542729405
GSE48662Up0.3062606947

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SorafenibDB00398 APRD01304 | DB07438
SunitinibDB01268 DB07417
VatalanibDB04879 -
TG100801DB05075 -
ABT-869DB06080 -
IMC-1C11DB06101 -
PazopanibDB06589 -
AxitinibDB06626 -
RegorafenibDB08896 -
LenvatinibDB09078 -
NintedanibDB09079 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-331-3pMIMAT0000760MIRT043539CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18355322Even when cultured for two months, the cells maintained endothelial cell properties, as assessed by expression of endothelium-specific markers and intracellular signaling through the vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3, as well as their physiological characteristics
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