HCSGD entry for PHLPP1
1. General information
| Official gene symbol | PHLPP1 |
|---|---|
| Entrez ID | 23239 |
| Gene full name | PH domain and leucine rich repeat protein phosphatase 1 |
| Other gene symbols | PHLPP PLEKHE1 SCOP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004721 | Phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009649 | Entrainment of circadian clock | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5780937274 | 0.3670277345 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2046538882 |
| GSE13712_SHEAR | Up | 0.2422699122 |
| GSE13712_STATIC | Up | 0.4564598526 |
| GSE19018 | Down | -0.0188291560 |
| GSE19899_A1 | Down | -0.0604106613 |
| GSE19899_A2 | Up | 0.1159700432 |
| PubMed_21979375_A1 | Up | 0.3506038461 |
| PubMed_21979375_A2 | Up | 0.4616344941 |
| GSE35957 | Down | -0.2338187350 |
| GSE36640 | Down | -0.7072180352 |
| GSE54402 | Down | -0.2910254380 |
| GSE9593 | Up | 0.0517381180 |
| GSE43922 | Up | 0.0093436841 |
| GSE24585 | Down | -0.1541370014 |
| GSE37065 | Down | -0.0050733873 |
| GSE28863_A1 | Up | 0.0331971287 |
| GSE28863_A2 | Up | 0.0186783372 |
| GSE28863_A3 | Up | 0.2278516831 |
| GSE28863_A4 | Down | -0.0726754027 |
| GSE48662 | Down | -0.1817241984 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-331-3p | MIMAT0000760 | MIRT019235 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-190a-5p | MIMAT0000458 | MIRT021082 | Reporter assay;Western blot | Functional MTI | 21750348 |
| hsa-miR-1307-3p | MIMAT0005951 | MIRT035820 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037351 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041846 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
