HCSGD entry for PLCB1

1. General information

Official gene symbolPLCB1
Entrez ID23236
Gene full namephospholipase C, beta 1 (phosphoinositide-specific)
Other gene symbolsEIEE12 PI-PLC PLC-154 PLC-I PLC154 PLCB1A PLCB1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleISSbiological_process
GO:0000790Nuclear chromatinISScellular_component
GO:0004435Phosphatidylinositol phospholipase C activityIEA ISS NASmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005096GTPase activator activityIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005516Calmodulin bindingIPImolecular_function
GO:0005521Lamin bindingIEAmolecular_function
GO:0005546Phosphatidylinositol-4,5-bisphosphate bindingIDAmolecular_function
GO:0005634NucleusIEA NAScellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007213G-protein coupled acetylcholine receptor signaling pathwayISSbiological_process
GO:0007215Glutamate receptor signaling pathwayISSbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007613MemoryISSbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayISSbiological_process
GO:0016042Lipid catabolic processIEAbiological_process
GO:0016607Nuclear speckIDAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0021987Cerebral cortex developmentISSbiological_process
GO:0031965Nuclear membraneIEAcellular_component
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0035722Interleukin-12-mediated signaling pathwayIDAbiological_process
GO:0035723Interleukin-15-mediated signaling pathwayIDAbiological_process
GO:0040019Positive regulation of embryonic developmentISSbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045444Fat cell differentiationIEAbiological_process
GO:0045663Positive regulation of myoblast differentiationISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0046488Phosphatidylinositol metabolic processISSbiological_process
GO:0048009Insulin-like growth factor receptor signaling pathwayISSbiological_process
GO:0048639Positive regulation of developmental growthISSbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0060466Activation of meiosis involved in egg activationISSbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIDAbiological_process
GO:0080154Regulation of fertilizationISSbiological_process
GO:1900087Positive regulation of G1/S transition of mitotic cell cycleISSbiological_process
GO:2000344Positive regulation of acrosome reactionISSbiological_process
GO:2000438Negative regulation of monocyte extravasationISSbiological_process
GO:2000560Positive regulation of CD24 biosynthetic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75159047910.01526514190.99999024730.2429224909

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2452635144
GSE13712_SHEARDown-0.2141649369
GSE13712_STATICDown-0.1697302089
GSE19018Down-0.0254874010
GSE19899_A1Down-0.6030037320
GSE19899_A2Down-1.3460224760
PubMed_21979375_A1Down-1.2799174688
PubMed_21979375_A2Down-0.9692359945
GSE35957Down-0.1693132293
GSE36640Down-0.0775414489
GSE54402Down-1.0969436572
GSE9593Up0.5525158593
GSE43922Down-0.3386941450
GSE24585Up0.1163585281
GSE37065Up0.2429602625
GSE28863_A1Up0.5445330153
GSE28863_A2Down-0.3464159762
GSE28863_A3Down-0.5207481186
GSE28863_A4Up0.1514458343
GSE48662Down-0.2501777086

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-423-5pMIMAT0004748MIRT038084CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047991CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.