HCSGD entry for FLT3

1. General information

Official gene symbolFLT3
Entrez ID2322
Gene full namefms-related tyrosine kinase 3
Other gene symbolsCD135 FLK-2 FLK2 STK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001776Leukocyte homeostasisISSbiological_process
GO:0002318Myeloid progenitor cell differentiationISSbiological_process
GO:0002328Pro-B cell differentiationISSbiological_process
GO:0002572Pro-T cell differentiationIEAbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEA TASmolecular_function
GO:0004896Cytokine receptor activityISSmolecular_function
GO:0005021Vascular endothelial growth factor-activated receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005788Endoplasmic reticulum lumenIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEA TASbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayISSbiological_process
GO:0030097HemopoiesisIDAbiological_process
GO:0030183B cell differentiationISSbiological_process
GO:0035726Common myeloid progenitor cell proliferationISSbiological_process
GO:0038084Vascular endothelial growth factor signaling pathwayTASbiological_process
GO:0042531Positive regulation of tyrosine phosphorylation of STAT proteinTASbiological_process
GO:0042803Protein homodimerization activityTASmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043406Positive regulation of MAP kinase activityTASbiological_process
GO:0043410Positive regulation of MAPK cascadeTASbiological_process
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityTASbiological_process
GO:0045578Negative regulation of B cell differentiationIEAbiological_process
GO:0046651Lymphocyte proliferationISSbiological_process
GO:0046777Protein autophosphorylationTASbiological_process
GO:0071345Cellular response to cytokine stimulusISS TASbiological_process
GO:0097028Dendritic cell differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47190918660.90798681280.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0216224272
GSE13712_SHEARDown-0.0877808949
GSE13712_STATICDown-0.1621277647
GSE19018Up0.0607334770
GSE19899_A1Up0.1164267246
GSE19899_A2Up0.1102229932
PubMed_21979375_A1Up0.0681999569
PubMed_21979375_A2Up0.1836653234
GSE35957Up0.0632767868
GSE36640Up0.0248041829
GSE54402Down-0.0533538886
GSE9593Up0.2347421698
GSE43922Up0.0131690189
GSE24585Up0.5060244418
GSE37065Down-0.0352639959
GSE28863_A1Up0.0414757668
GSE28863_A2Up0.0099977479
GSE28863_A3Up0.1457220585
GSE28863_A4Down-0.0180047532
GSE48662Up0.0308180961

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SorafenibDB00398 APRD01304 | DB07438
SunitinibDB01268 DB07417
XL999DB05014 -
AC220DB05213 -
MP470DB05216 -
MLN-518DB05465 -
ABT-869DB06080 -
PonatinibDB08901 -
NintedanibDB09079 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-150-5pMIMAT0000451MIRT007053Luciferase reporter assayFunctional MTI23079661
hsa-miR-335-5pMIMAT0000765MIRT017462MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.