HCSGD entry for MLC1

1. General information

Official gene symbolMLC1
Entrez ID23209
Gene full namemegalencephalic leukoencephalopathy with subcortical cysts 1
Other gene symbolsLVM MLC VL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005215Transporter activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIEA ISScellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005769Early endosomeIEA ISScellular_component
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005901CaveolaIEA ISScellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0006810TransportNASbiological_process
GO:0006811Ion transportIEAbiological_process
GO:0008565Protein transporter activityIEA ISSmolecular_function
GO:0016021Integral component of membraneIDAcellular_component
GO:0016192Vesicle-mediated transportISSbiological_process
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030136Clathrin-coated vesicleISScellular_component
GO:0031410Cytoplasmic vesicleIDA IEAcellular_component
GO:0032388Positive regulation of intracellular transportIDAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0045121Membrane raftISScellular_component
GO:0047484Regulation of response to osmotic stressIMPbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051259Protein oligomerizationIDAbiological_process
GO:0055037Recycling endosomeIEA ISScellular_component
GO:0071397Cellular response to cholesterolIEA ISSbiological_process
GO:0072584Caveolin-mediated endocytosisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64120599900.80629201020.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0071346138
GSE13712_SHEARDown-0.2135513691
GSE13712_STATICUp0.2050438827
GSE19018Up0.0956882175
GSE19899_A1Down-0.0237673565
GSE19899_A2Up0.0120237086
PubMed_21979375_A1Down-0.1849272740
PubMed_21979375_A2Up0.0479701263
GSE35957Down-0.0471620524
GSE36640Up0.1028263863
GSE54402Up0.0117884636
GSE9593Up0.0678584696
GSE43922Up0.1062861592
GSE24585Down-0.0640350646
GSE37065Down-0.1530108388
GSE28863_A1Up0.0114411133
GSE28863_A2Up0.0803518894
GSE28863_A3Up0.3080450734
GSE28863_A4Up0.0524525422
GSE48662Down-0.0359296870

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017034MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.