HCSGD entry for LPIN1
1. General information
| Official gene symbol | LPIN1 |
|---|---|
| Entrez ID | 23175 |
| Gene full name | lipin 1 |
| Other gene symbols | PAP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000266 | Mitochondrial fission | IEA | biological_process |
| GO:0001085 | RNA polymerase II transcription factor binding | IEA | molecular_function |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003713 | Transcription coactivator activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006642 | Triglyceride mobilization | IEA ISS | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006646 | Phosphatidylethanolamine biosynthetic process | TAS | biological_process |
| GO:0006656 | Phosphatidylcholine biosynthetic process | TAS | biological_process |
| GO:0008195 | Phosphatidate phosphatase activity | IEA | molecular_function |
| GO:0009062 | Fatty acid catabolic process | IEA ISS | biological_process |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0031065 | Positive regulation of histone deacetylation | IEA | biological_process |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0031529 | Ruffle organization | IEA | biological_process |
| GO:0031532 | Actin cytoskeleton reorganization | IEA | biological_process |
| GO:0031965 | Nuclear membrane | ISS | cellular_component |
| GO:0032869 | Cellular response to insulin stimulus | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IEA | molecular_function |
| GO:0042975 | Peroxisome proliferator activated receptor binding | IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045598 | Regulation of fat cell differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0012738346 | 0.8014793929 | 0.0963465517 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6142174825 |
| GSE13712_SHEAR | Up | 0.2031015158 |
| GSE13712_STATIC | Up | 0.3565009208 |
| GSE19018 | Up | 0.0964292970 |
| GSE19899_A1 | Up | 1.3674458956 |
| GSE19899_A2 | Up | 2.0584856152 |
| PubMed_21979375_A1 | Up | 1.3248375194 |
| PubMed_21979375_A2 | Up | 1.7639034312 |
| GSE35957 | Up | 0.2056511341 |
| GSE36640 | Up | 1.5185562737 |
| GSE54402 | Up | 0.6689675203 |
| GSE9593 | Up | 0.2832296045 |
| GSE43922 | Up | 0.7073668241 |
| GSE24585 | Down | -1.0679694754 |
| GSE37065 | Up | 0.0237004439 |
| GSE28863_A1 | Up | 0.0781525694 |
| GSE28863_A2 | Up | 0.6622891262 |
| GSE28863_A3 | Down | -0.4759610793 |
| GSE28863_A4 | Down | -0.3373199957 |
| GSE48662 | Up | 0.0520240335 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018934 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049016 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050981 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27391332 | Finally, during adipocyte differentiation of adipose-derived human mesenchymal stem cells, the expression of adipogenic genes (PPARG, LPIN1, and LPL) increased significantly over 14 days, and noteworthy is that the BSCL2 transcript without exon 7 was differentially expressed by 332 to 723% when compared to day 0, suggesting an underlying role in adipogenesis |
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