HCSGD entry for FLNA
1. General information
| Official gene symbol | FLNA |
|---|---|
| Entrez ID | 2316 |
| Gene full name | filamin A, alpha |
| Other gene symbols | ABP-280 ABPX CSBS CVD1 FLN FLN-A FLN1 FMD MNS NHBP OPD OPD1 OPD2 XLVD XMVD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001837 | Epithelial to mesenchymal transition | IEA | biological_process |
| GO:0001948 | Glycoprotein binding | IDA | molecular_function |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0005080 | Protein kinase C binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005884 | Actin filament | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007195 | Adenylate cyclase-inhibiting dopamine receptor signaling pathway | IMP | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0015629 | Actin cytoskeleton | IC IDA | cellular_component |
| GO:0017048 | Rho GTPase binding | IDA | molecular_function |
| GO:0017160 | Ral GTPase binding | IDA | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030863 | Cortical cytoskeleton | IEA | cellular_component |
| GO:0031267 | Small GTPase binding | IDA | molecular_function |
| GO:0031523 | Myb complex | IDA | cellular_component |
| GO:0031532 | Actin cytoskeleton reorganization | IDA | biological_process |
| GO:0031852 | Mu-type opioid receptor binding | IEA | molecular_function |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034394 | Protein localization to cell surface | IDA | biological_process |
| GO:0034988 | Fc-gamma receptor I complex binding | IDA | molecular_function |
| GO:0042177 | Negative regulation of protein catabolic process | IMP | biological_process |
| GO:0042384 | Cilium assembly | IMP | biological_process |
| GO:0042789 | MRNA transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0042993 | Positive regulation of transcription factor import into nucleus | IMP | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043113 | Receptor clustering | IDA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0043198 | Dendritic shaft | IEA | cellular_component |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0045022 | Early endosome to late endosome transport | IEA | biological_process |
| GO:0045184 | Establishment of protein localization | IDA | biological_process |
| GO:0046332 | SMAD binding | IEA | molecular_function |
| GO:0048365 | Rac GTPase binding | IDA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050821 | Protein stabilization | IMP | biological_process |
| GO:0051015 | Actin filament binding | IDA | molecular_function |
| GO:0051220 | Cytoplasmic sequestering of protein | IMP | biological_process |
| GO:0051764 | Actin crosslink formation | IDA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0090307 | Spindle assembly involved in mitosis | IDA | biological_process |
| GO:0097440 | Apical dendrite | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9400601155 | 0.0019859770 | 0.9999902473 | 0.0850970732 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.4466088384 |
| GSE13712_SHEAR | Down | -0.3176127004 |
| GSE13712_STATIC | Down | -0.2236549442 |
| GSE19018 | Down | -0.2877768626 |
| GSE19899_A1 | Down | -1.3200209174 |
| GSE19899_A2 | Down | -0.9257672608 |
| PubMed_21979375_A1 | Up | 0.3947117519 |
| PubMed_21979375_A2 | Up | 0.2623803036 |
| GSE35957 | Down | -0.3297076068 |
| GSE36640 | Down | -0.2708473408 |
| GSE54402 | Down | -0.7771316777 |
| GSE9593 | Down | -0.2092275626 |
| GSE43922 | Down | -0.4924941897 |
| GSE24585 | Down | -1.1512861750 |
| GSE37065 | Down | -0.6262602200 |
| GSE28863_A1 | Up | 0.5375079405 |
| GSE28863_A2 | Up | 0.2837241928 |
| GSE28863_A3 | Down | -0.0781725435 |
| GSE28863_A4 | Down | -0.1767918709 |
| GSE48662 | Down | -0.3058191059 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020648 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023757 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023757 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025777 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039798 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040564 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041256 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042059 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043054 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043388 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043955 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT044384 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045578 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046250 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046811 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046888 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048229 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049560 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049870 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050388 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050582 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051288 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052184 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
