HCSGD entry for SMC5
1. General information
| Official gene symbol | SMC5 |
|---|---|
| Entrez ID | 23137 |
| Gene full name | structural maintenance of chromosomes 5 |
| Other gene symbols | SMC5L1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000722 | Telomere maintenance via recombination | IMP | biological_process |
| GO:0000724 | Double-strand break repair via homologous recombination | IMP | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IMP | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0030915 | Smc5-Smc6 complex | IDA | cellular_component |
| GO:0034184 | Positive regulation of maintenance of mitotic sister chromatid cohesion | IMP | biological_process |
| GO:0045842 | Positive regulation of mitotic metaphase/anaphase transition | IMP | biological_process |
| GO:0090398 | Cellular senescence | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9720872915 | 0.0557510277 | 0.9999902473 | 0.4441352300 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2764939414 |
| GSE13712_SHEAR | Down | -0.0184317672 |
| GSE13712_STATIC | Up | 0.2088812197 |
| GSE19018 | Down | -0.0789783484 |
| GSE19899_A1 | Down | -0.1936096083 |
| GSE19899_A2 | Down | -0.4464756009 |
| PubMed_21979375_A1 | Down | -0.4178843370 |
| PubMed_21979375_A2 | Down | -0.1782653435 |
| GSE35957 | Down | -0.3835433682 |
| GSE36640 | Down | -0.5748390517 |
| GSE54402 | Down | -0.2653390330 |
| GSE9593 | Down | -0.2373331917 |
| GSE43922 | Down | -0.0315971759 |
| GSE24585 | Down | -0.1066557604 |
| GSE37065 | Down | -0.0352883593 |
| GSE28863_A1 | Up | 0.3078777390 |
| GSE28863_A2 | Up | 0.0472892717 |
| GSE28863_A3 | Down | -0.1000070071 |
| GSE28863_A4 | Up | 0.0945634569 |
| GSE48662 | Down | -0.5228154815 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20159973 | One target of Mms21-dependent sumoylation is the cohesin- and condensin-related Smc5-Smc6 complex (Smc5/6) |
| 20159973 | Further, we provide evidence that Mms21 and Smc5/6 prevent aberrant recombination between sister telomeres and also globally facilitate resolution of sister chromatid HR intermediates |
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