HCSGD entry for ERC1
1. General information
| Official gene symbol | ERC1 |
|---|---|
| Entrez ID | 23085 |
| Gene full name | ELKS/RAB6-interacting/CAST family member 1 |
| Other gene symbols | Cast2 ELKS RAB6IP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0007252 | I-kappaB phosphorylation | IDA | biological_process |
| GO:0007275 | Multicellular organismal development | NAS | biological_process |
| GO:0008385 | IkappaB kinase complex | IDA | cellular_component |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0017137 | Rab GTPase binding | IEA | molecular_function |
| GO:0042147 | Retrograde transport, endosome to Golgi | IEA | biological_process |
| GO:0042734 | Presynaptic membrane | TAS | cellular_component |
| GO:0043522 | Leucine zipper domain binding | NAS | molecular_function |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1103607082 | 0.8905438319 | 0.6876469729 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0466341610 |
| GSE13712_SHEAR | Down | -0.3033919964 |
| GSE13712_STATIC | Down | -0.3808344719 |
| GSE19018 | Up | 0.0010492509 |
| GSE19899_A1 | Down | -0.0166237204 |
| GSE19899_A2 | Down | -0.0566597795 |
| PubMed_21979375_A1 | Up | 0.2996539896 |
| PubMed_21979375_A2 | Up | 0.5287047524 |
| GSE35957 | Up | 0.4065158987 |
| GSE36640 | Up | 0.1271246695 |
| GSE54402 | Down | -0.1184193784 |
| GSE9593 | Up | 0.5719463210 |
| GSE43922 | Up | 0.0938388926 |
| GSE24585 | Up | 0.2429606015 |
| GSE37065 | Down | -0.0233609467 |
| GSE28863_A1 | Up | 0.3329297410 |
| GSE28863_A2 | Up | 0.3085881161 |
| GSE28863_A3 | Up | 0.1080569391 |
| GSE28863_A4 | Up | 0.0904492598 |
| GSE48662 | Up | 0.0820774118 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005238 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017354 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT024998 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029212 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032135 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320b | MIMAT0005792 | MIRT036190 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036316 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044468 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046960 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
