HCSGD entry for PPRC1
1. General information
| Official gene symbol | PPRC1 |
|---|---|
| Entrez ID | 23082 |
| Gene full name | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| Other gene symbols | PRC RP11-302K17.6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2465934577 | 0.0726253220 | 0.9349738743 | 0.5079912570 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3235391637 |
| GSE13712_SHEAR | Up | 0.1511774404 |
| GSE13712_STATIC | Up | 0.1325402061 |
| GSE19018 | Down | -0.8997621055 |
| GSE19899_A1 | Up | 0.0227369748 |
| GSE19899_A2 | Up | 0.4080175128 |
| PubMed_21979375_A1 | Up | 0.2870250627 |
| PubMed_21979375_A2 | Up | 1.4053968735 |
| GSE35957 | Down | -0.5817231175 |
| GSE36640 | Down | -0.5876363693 |
| GSE54402 | Up | 0.4293325842 |
| GSE9593 | Down | -0.5505344724 |
| GSE43922 | Up | 0.0462599401 |
| GSE24585 | Down | -0.8553013701 |
| GSE37065 | Down | -0.2291121409 |
| GSE28863_A1 | Up | 0.0681671267 |
| GSE28863_A2 | Up | 0.3878182367 |
| GSE28863_A3 | Up | 0.0413742586 |
| GSE28863_A4 | Down | -0.0160858750 |
| GSE48662 | Down | -0.2439819138 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022950 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025837 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027703 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038413 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039315 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045265 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046595 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047060 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051899 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26102775 | The ReninSense 680 probe showed increased intrarenal renin activity in Ercc1d/- mice versus Ercc1+/+ mice, both at 12 and 18 weeks of age, while PRC in these mice tended to be lower compared to Ercc1+/+ mice |
| 25406515 | In proliferating cells, SAFA and PANDA recruit PRC complexes to repress the transcription of senescence-promoting genes |
| 24067365 | Here we provide evidence for the regulation of additional senescence-associated PRC target genes by HLX1 and HOXA9 |
| 21736542 | These findings suggest that chromatin-remodeling factors, including the PRC complex controlled by JDP2, are important players in the senescence |
| 21197464 | Therefore, it seems that chromatin-remodeling factors, including the PRC complex controlled by JDP2, may be important players in the senescence program |
| 20808772 | Zfp277 binds to the Ink4a/Arf locus in a Bmi1-independent manner and interacts with polycomb repressor complex (PRC) 1 through direct interaction with Bmi1 |
| 19954516 | During progenitor cell differentiation and ageing, PcG silencer EZH2 attenuates, causing loss of PRC binding and transcriptional activation of INK4b and INK4a |
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