HCSGD entry for KDM4C
1. General information
| Official gene symbol | KDM4C |
|---|---|
| Entrez ID | 23081 |
| Gene full name | lysine (K)-specific demethylase 4C |
| Other gene symbols | GASC1 JHDM3C JMJD2C TDRD14C bA146B14.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0019899 | Enzyme binding | IEA IPI | molecular_function |
| GO:0032454 | Histone demethylase activity (H3-K9 specific) | IDA IMP | molecular_function |
| GO:0033169 | Histone H3-K9 demethylation | IDA IMP | biological_process |
| GO:0050681 | Androgen receptor binding | IEA IPI | molecular_function |
| GO:0051213 | Dioxygenase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2921353254 | 0.6500986361 | 0.9919440531 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2160940462 |
| GSE13712_SHEAR | Up | 0.0227629561 |
| GSE13712_STATIC | Up | 0.0722677606 |
| GSE19018 | Up | 0.3573353728 |
| GSE19899_A1 | Up | 0.2026704902 |
| GSE19899_A2 | Up | 0.1841925584 |
| PubMed_21979375_A1 | Up | 0.3889197674 |
| PubMed_21979375_A2 | Up | 0.4242166734 |
| GSE35957 | Down | -0.1594392669 |
| GSE36640 | Up | 0.0680404016 |
| GSE54402 | Up | 0.0186525493 |
| GSE9593 | Down | -0.1663434058 |
| GSE43922 | Up | 0.2782362300 |
| GSE24585 | Up | 0.1077376316 |
| GSE37065 | Up | 0.1447163224 |
| GSE28863_A1 | Up | 0.2318864098 |
| GSE28863_A2 | Down | -0.0028492585 |
| GSE28863_A3 | Down | -0.5521663548 |
| GSE28863_A4 | Down | -0.1652707583 |
| GSE48662 | Down | -0.3422455693 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016783 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27114850 | HIF-1alpha stimulates the expression of KDM3A, KDM4B, KDM4C, and KDM6B, which enhance gene transcription by demethylating H3K9 and H3K27 sites (repressive epigenetic marks) |
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